The Effects of Nutritional Juice Supplementation on the Extent of Climacteric Symptoms: An Observational Study

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2016 Sep 27

PMID 27668002

Citations 1

Authors

Stefanie I Siebler

Ursula Gresser

Barbara M Richartz

Affiliations

Soon will be listed here.

Abstract

Objective. This study aims to evaluate the effect of daily dietary nutritional supplement on somatic, psychological, and urogenital symptoms in postmenopausal women. Material and Methods. In this study 28 healthy, symptomatic, peri- and postmenopausal women of 47-67 years of age were allocated to use the nutritional supplement JuicePLUS+®. Primary research parameters: Menopause Rating Scale (MRS) was used to assess menopausal symptoms at baseline and after 8 and 16 weeks of treatment. Secondary parameters: proliferation behaviour of vaginal smear was scored at baseline and after treatment. Results. Treatment with the supplement resulted in a reduction of somatic, psychological, and urogenital symptoms. The overall MRS score showed an average improvement of 44.01%. Most benefits were observed for the psychological symptoms irritability (60.55%) and physical and mental exhaustion (49.08%); modest effects were observed for hot flashes (44.86%) and sleeping problems (35.56%). There was a minor improvement in sexual problems; 6 women reported an increased libido. No statistically significant effect was found in vaginal dryness and proliferation behaviour of vaginal mucosa. No adverse effects were observed. Conclusion. Dietary nutritional supplement may constitute an effective alternative therapy to conventional alternative medicine for somatic, psychological, and sexual symptoms.

Citing Articles

Nutritional interventions in treating menopause-related sleep disturbances: a systematic review.

Polasek D, Santhi N, Alfonso-Miller P, Walshe I, Haskell-Ramsay C, Elder G Nutr Rev. 2023; 82(8):1087-1110.

PMID: 37695299 PMC: 11233886. DOI: 10.1093/nutrit/nuad113.

References

Gold E, Colvin A, Avis N, Bromberger J, Greendale G, Powell L . Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women's health across the nation. Am J Public Health. 2006; 96(7):1226-35. PMC: 1483882. DOI: 10.2105/AJPH.2005.066936. View

Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J . Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev. 2013; (12):CD001395. PMC: 10247921. DOI: 10.1002/14651858.CD001395.pub4. View

Beer A, Neff A . Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints. Evid Based Complement Alternat Med. 2013; 2013:860602. PMC: 3767045. DOI: 10.1155/2013/860602. View

Carmignani L, Pedro A, Costa-Paiva L, Pinto-Neto A . The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: a randomized controlled trial. Maturitas. 2010; 67(3):262-9. DOI: 10.1016/j.maturitas.2010.07.007. View

Melby M, Anderson D, Sievert L, Obermeyer C . Methods used in cross-cultural comparisons of vasomotor symptoms and their determinants. Maturitas. 2011; 70(2):110-9. DOI: 10.1016/j.maturitas.2011.07.010. View

Faure E, Chantre P, Mares P . Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause. 2002; 9(5):329-34. DOI: 10.1097/00042192-200209000-00005. View

Barazzetti L, Pattussi M, da Silva Garcez A, Mendes K, Theodoro H, Paniz V . Psychiatric disorders and menopause symptoms in Brazilian women. Menopause. 2015; 23(4):433-40. DOI: 10.1097/GME.0000000000000548. View

Buhling K, Daniels B, Studnitz F, Eulenburg C, Mueck A . The use of complementary and alternative medicine by women transitioning through menopause in Germany: results of a survey of women aged 45-60 years. Complement Ther Med. 2014; 22(1):94-8. DOI: 10.1016/j.ctim.2013.12.004. View

Gold E, Bromberger J, Crawford S, Samuels S, Greendale G, Harlow S . Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am J Epidemiol. 2001; 153(9):865-74. DOI: 10.1093/aje/153.9.865. View

10.

Esfahani A, Wong J, Truan J, Villa C, Mirrahimi A, Srichaikul K . Health effects of mixed fruit and vegetable concentrates: a systematic review of the clinical interventions. J Am Coll Nutr. 2011; 30(5):285-94. DOI: 10.1080/07315724.2011.10719971. View

11.

Carmignani L, Pedro A, Montemor E, Arias V, Costa-Paiva L, Pinto-Neto A . Effects of a soy-based dietary supplement compared with low-dose hormone therapy on the urogenital system: a randomized, double-blind, controlled clinical trial. Menopause. 2014; 22(7):741-9. DOI: 10.1097/GME.0000000000000380. View

12.

Samman S, Sivarajah G, Man J, Ahmad Z, Petocz P, Caterson I . A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. J Nutr. 2003; 133(7):2188-93. DOI: 10.1093/jn/133.7.2188. View

13.

Nelson H, Vesco K, Haney E, Fu R, Nedrow A, Miller J . Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA. 2006; 295(17):2057-71. DOI: 10.1001/jama.295.17.2057. View

14.

Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin H . Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005; 105(5 Pt 1):1074-83. DOI: 10.1097/01.AOG.0000158865.98070.89. View

15.

Sanhueza C, Ryan L, Foxcroft D . Diet and the risk of unipolar depression in adults: systematic review of cohort studies. J Hum Nutr Diet. 2012; 26(1):56-70. DOI: 10.1111/j.1365-277X.2012.01283.x. View

16.

Nelson H, Haney E, Humphrey L, Miller J, Nedrow A, Nicolaidis C . Management of menopause-related symptoms. Evid Rep Technol Assess (Summ). 2005; (120):1-6. PMC: 4782129. View

17.

Kreijkamp-Kaspers S, Kok L, Grobbee D, de Haan E, Aleman A, Lampe J . Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA. 2004; 292(1):65-74. DOI: 10.1001/jama.292.1.65. View

18.

Uebelhack R, Blohmer J, Graubaum H, Busch R, Gruenwald J, Wernecke K . Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Obstet Gynecol. 2006; 107(2 Pt 1):247-55. DOI: 10.1097/01.AOG.0000196504.49378.83. View

19.

Shakeri F, Taavoni S, Goushegir A, Haghani H . Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric. 2015; 18(4):568-73. DOI: 10.3109/13697137.2014.999660. View

20.

Cain V, Johannes C, Avis N, Mohr B, Schocken M, Skurnick J . Sexual functioning and practices in a multi-ethnic study of midlife women: baseline results from SWAN. J Sex Res. 2003; 40(3):266-76. DOI: 10.1080/00224490309552191. View