Association of Vitamin D Deficiency with Hepatitis B Virus - Related Liver Diseases

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2016 Sep 24

PMID 27659316

Citations 26

Authors

Nghiem Xuan Hoan

Nguyen Khuyen

Mai Thanh Binh

Dao Phuong Giang

Hoang Van Tong

Phan Quoc Hoan

Ngo Tat Trung

Do Tuan Anh

Nguyen Linh Toan

Christian G Meyer

Peter G Kremsner

Thirumalaisamy P Velavan

Le Huu Song

Affiliations

Soon will be listed here.

Abstract

Background: As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls.

Methods: We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters.

Results: The prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV-DNA load were strongly and inversely correlated (rho = -0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV-DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016).

Conclusions: Vitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders.

Citing Articles

Correlations of Serum Vitamin D Level with Markers of Oxidative Stress and Apoptosis in Liver Cirrhosis.

Pomacu M, Trasca D, Padureanu V, Stanciulescu E, Busuioc C, Pisoschi C Curr Health Sci J. 2023; 49(1):54-66.

PMID: 37780191 PMC: 10541071. DOI: 10.12865/CHSJ.49.01.54.

Chronic Hepatitis B and Related Liver Diseases Are Associated with Reduced 25-Hydroxy-Vitamin D Levels: A Systematic Review and Meta-Analysis.

Banerjee A, Athalye S, Khargekar N, Shingade P, Madkaikar M Biomedicines. 2023; 11(1).

PMID: 36672644 PMC: 9855868. DOI: 10.3390/biomedicines11010135.

Vitamin D role in hepatitis B: focus on immune system and genetics mechanism.

Asghari A, Jafari F, Jameshorani M, Chiti H, Naseri M, Ghafourirankouhi A Heliyon. 2022; 8(11):e11569.

PMID: 36411916 PMC: 9674901. DOI: 10.1016/j.heliyon.2022.e11569.

The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases.

Pop T, Sirbe C, Benta G, Mititelu A, Grama A Int J Mol Sci. 2022; 23(18).

PMID: 36142636 PMC: 9503777. DOI: 10.3390/ijms231810705.

Reducing Virus Infection Risk in Space Environments through Nutrient Supplementation.

Li H, Xue Y, Quan Y, Zhang H Genes (Basel). 2022; 13(9).

PMID: 36140704 PMC: 9498414. DOI: 10.3390/genes13091536.

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