Germinal Center B Cell Dynamics

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2016 Sep 23

PMID 27653600

Citations 509

Authors

Luka Mesin

Jonatan Ersching

Gabriel D Victora

Affiliations

Soon will be listed here.

Abstract

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

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