Predictive Value of Cytokines for Developing Complications After Polytrauma

Overview

Journal World J Crit Care Med

Publisher Baishideng Publishing Group

Specialty Critical Care

Date 2016 Sep 22

PMID 27652210

Citations 11

Authors

Anne-Britt E Dekker

Pieta Krijnen

Inger B Schipper

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate posttraumatic cytokine alterations and their value for predicting complications and mortality in polytraumatized patients.

Methods: Studies on the use of specific cytokines to predict the development of complications and mortality were identified in MEDLINE, EMBASE, Web of Science and the Cochrane Library. Of included studies, relevant data were extracted and study quality was scored.

Results: Forty-two studies published between 1988 and 2015 were identified, including 28 cohort studies and 14 "nested" case-control studies. Most studies investigated the cytokines interleukin (IL)-6, IL-8, IL-10 and tumor necrosis factor (TNF-α). IL-6 seems related to muliorgan dysfunction syndrome, multiorgan failure (MOF) and mortality; IL-8 appears altered in acute respiratory distress syndrome, MOF and mortality; IL-10 alterations seem to precede sepsis and MOF; and TNF-α seems related to MOF.

Conclusion: Cytokine secretion patterns appear to be different for patients developing complications when compared to patients with uneventful posttraumatic course. More research is needed to strengthen the evidence for clinical relevance of these cytokines.

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Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.

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