Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio Fluvialis Isolated from Diarrheal Samples

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2016 Sep 21

PMID 27649032

Citations 14

Authors

Goutam Chowdhury

Gururaja Perumal Pazhani

Anirban Sarkar

Krishnan Rajendran

Asish K Mukhopadhyay

Mihir K Bhattacharya

Amit Ghosh

Thandavarayan Ramamurthy

Affiliations

Soon will be listed here.

Abstract

Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1-expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis-harboring blaNDM-1 (NDM-VF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline. The large plasmid of V. fluvialis harboring blaNDM-1 could be easily transferred to other enteric pathogens. Genes flanking the blaNDM-1 were found to be identical to the reported sequence from an Escherichia coli isolate. Analyses showed that the V. fluvialis possessing the NDM-VF region belonged to different clones. The pathogenicity of V. fluvialis to humans and its ubiquitous presence in the environment call for constant monitoring of this species for emerging antimicrobial drug resistance.

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