Skeletal Muscle Metastases on Magnetic Resonance Imaging: Analysis of 31 Cases

Overview

Journal Contemp Oncol (Pozn)

Publisher Termedia

Specialty Oncology

Date 2016 Sep 21

PMID 27647989

Citations 4

Authors

Qi Li

Lei Wang

Shinong Pan

Hong Shu

Ying Ma

Zaiming Lu

Xihu Fu

Bo Jiang

Qiyong Guo

Affiliations

Soon will be listed here.

Abstract

Aim Of The Study: To investigate the magnetic resonance imaging (MRI) features of skeletal muscle metastases (SMM).

Material And Methods: The records of 31 patients with proven SMM were retrospectively reviewed. Clinical history, type of primary malignancy, location of metastases, and MRI features of SMM were evaluated. Based on MRI findings, SMM were divided into three MRI types. The correlation between MRI types with ages and pathology category, between MRI types of SMM and ages, as well as MRI types of SMM and pathology category were analysed with Spearman's rho.

Results: The most common primary tumour was genital tumour (25.8%) and bronchial carcinoma (19.4%), and the most common cell type was adenocarcinoma (58.1%). SMM were located in the iliopsoas muscle (26.3%), paravertebral muscles (21.1%), and upper extremity muscles (18.4%). MRI features: (1) Type-I localised lesions (12.90%), round-like mass limited to local regions with heterogeneous iso-signal intensity in T1WI and heterogeneous hyper-intensity in T2WI; (2) Type-II diffuse lesions without bone destruction (35.48%), abnormal diffuse swelling of the muscle with irregular boundaries and slightly hypo- to iso-intensity in T1WI and hyper-intensity in T2WI; and (3) Type-III diffuse lesions with bone destruction (51.61%), distinct irregular lump with iso-intensity in T1WI and heterogeneous hyper-intensity in T2WI with adjacent bone invasion. There was positive correlation between MRI types and ages (r = 0.431, p < 0.05). There were no significant differences of MRI types with pathology category (p > 0.05).

Conclusions: SMM features on MRI can be broadly used to classify lesions, which is beneficial for SMM diagnosis.

Citing Articles

An Unusual Case of Lung Adenocarcinoma Metastasis to the Tricep Muscle: Four Years Disease-Free After Surgical Resection and Radiotherapy.

Weeraddana P, Walgamage T, Elkabbani R, Dmitriev M, Crespo-Quezada J, Dandwani M Cureus. 2023; 15(4):e38347.

PMID: 37261157 PMC: 10229103. DOI: 10.7759/cureus.38347.

Skeletal muscle metastases of hepatocellular carcinoma: A case report and literature review.

Song Q, Sun X, Wu X, Dong Y, Wang L World J Clin Cases. 2021; 9(14):3334-3341.

PMID: 34002142 PMC: 8107905. DOI: 10.12998/wjcc.v9.i14.3334.

EML4-ALK positive lung adenocarcinoma with skeletal muscle metastasis in the right calf which was treatable with lorlatinib after resistance to treatment with alectinib.

Matsuda H, Hara M, Iwakami S, Takahashi K BMJ Case Rep. 2021; 14(4).

PMID: 33906872 PMC: 8088238. DOI: 10.1136/bcr-2020-240295.

Skeletal Muscle Metastasis to Vastus Lateralis from a Urothelial Carcinoma: A Case Report and Review of Its Diagnosis and Management.

Mainwaring A, Wells H, Banks T, Ellul T, Bose P Case Rep Urol. 2019; 2019:8923780.

PMID: 31886014 PMC: 6914937. DOI: 10.1155/2019/8923780.

References

Acinas Garcia O, Fernandez F, Satue E, Buelta L, Val-Bernal J . Metastasis of malignant neoplasms to skeletal muscle. Rev Esp Oncol. 1984; 31(1):57-67. View

Jiang H, Wang Z, Xian J, Li J, Zhao P . [Age-related changes of normal adult inferior rectus muscle:analysis with dynamic contrast-enhanced magnetic resonance imaging]. Zhonghua Yi Xue Za Zhi. 2011; 91(27):1899-903. View

Tang Y, Stuckey S, Lambie D, Strutton G . Macroscopic vascular invasion in synovial sarcoma evident on MRI. Skeletal Radiol. 2005; 35(10):783-6. DOI: 10.1007/s00256-005-0934-7. View

Parsa R, Yang A, McKeon F, Green H . Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999; 113(6):1099-105. DOI: 10.1046/j.1523-1747.1999.00780.x. View

Moon Y, Ahn K, Moon S, Lim S, Venkat G . Subscapularis muscle metastases of duodenal adenocarcinoma: a case report. J Shoulder Elbow Surg. 2009; 19(2):e18-21. DOI: 10.1016/j.jse.2009.09.003. View

Suto Y, Yamaguchi Y, Sugihara S . Skeletal muscle metastasis from lung carcinoma: MR findings. J Comput Assist Tomogr. 1997; 21(2):304-5. DOI: 10.1097/00004728-199703000-00027. View

Saotome T, Sekino M, Eto F, Ueno S . Evaluation of diffusional anisotropy and microscopic structure in skeletal muscles using magnetic resonance. Magn Reson Imaging. 2006; 24(1):19-25. DOI: 10.1016/j.mri.2005.09.009. View

Munk P, Gock S, Gee R, Connell D, Quenville N . Case report 708: Metastasis of renal cell carcinoma to skeletal muscle (right trapezius). Skeletal Radiol. 1992; 21(1):56-9. DOI: 10.1007/BF00243097. View

Koike Y, Hatori M, Kokubun S . Skeletal muscle metastasis secondary to cancer--a report of seven cases. Ups J Med Sci. 2005; 110(1):75-83. DOI: 10.3109/2000-1967-183. View

10.

Hasselman C, Best T, Hughes 4th C, Martinez S, Garrett Jr W . An explanation for various rectus femoris strain injuries using previously undescribed muscle architecture. Am J Sports Med. 1995; 23(4):493-9. DOI: 10.1177/036354659502300421. View

11.

Broome D, Girguis M, Baron P, Cottrell A, Kjellin I, Kirk G . Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned. AJR Am J Roentgenol. 2007; 188(2):586-92. DOI: 10.2214/ajr.06.1094. View

12.

Surov A, Hainz M, Holzhausen H, Arnold D, Katzer M, Schmidt J . Skeletal muscle metastases: primary tumours, prevalence, and radiological features. Eur Radiol. 2009; 20(3):649-58. DOI: 10.1007/s00330-009-1577-1. View

13.

Laban M, Tamler M, Wang A, Meerschaert J . Electromyographic detection of paraspinal muscle metastasis. Correlation with magnetic resonance imaging. Spine (Phila Pa 1976). 1992; 17(10):1144-7. DOI: 10.1097/00007632-199210000-00003. View

14.

Asuthkar S, Stepanova V, Lebedeva T, Holterman A, Estes N, Cines D . Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer. Mol Biol Cell. 2013; 24(17):2620-32. PMC: 3756915. DOI: 10.1091/mbc.E12-04-0306. View

15.

Koplas M, Lefkowitz R, Bauer T, Joyce M, Ilaslan H, Landa J . Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. Skeletal Radiol. 2009; 39(8):791-8. DOI: 10.1007/s00256-009-0822-7. View

16.

Glockner J, Sundaram M, White L . Incidence of solitary soft-tissue metastases revealed by MR imaging. AJR Am J Roentgenol. 2002; 179(6):1644; author reply 1644. DOI: 10.2214/ajr.179.6.1791644a. View

17.

Schmidt G, Reiser M, Baur-Melnyk A . Whole-body imaging of the musculoskeletal system: the value of MR imaging. Skeletal Radiol. 2007; 36(12):1109-19. PMC: 2042033. DOI: 10.1007/s00256-007-0323-5. View

18.

Nguyen B, Brandser E, Rubin D . Pains, strains, and fasciculations: lower extremity muscle disorders. Magn Reson Imaging Clin N Am. 2000; 8(2):391-408. View

19.

Saupe N, White L, Stainsby J, Tomlinson G, Sussman M . Diffusion tensor imaging and fiber tractography of skeletal muscle: optimization of B value for imaging at 1.5 T. AJR Am J Roentgenol. 2009; 192(6):W282-90. DOI: 10.2214/AJR.08.1340. View

20.

Ouyang L, Jia Q, Xiao Y, Ke L, He P . Magnetic resonance imaging: a valuable method for diagnosing chronic lumbago caused by lumbar muscle strain and monitoring healing process. Chin Med J (Engl). 2013; 126(13):2465-71. View