Effects of Idebenone and Related Compounds on Respiratory Activities of Brain Mitochondria, and on Lipid Peroxidation of Their Membranes

Overview

Journal Arch Gerontol Geriatr

Specialty Geriatrics

Date 1989 May 1

PMID 2764646

Citations 8

Authors

I IMADA

T Fujita

Y Sugiyama

K Okamoto

Y Kobayashi

Affiliations

Soon will be listed here.

Abstract

The oxidation of succinate and NADH in a ubiquinone-depleted canine brain mitochondrial preparation was restored by a low molecular weight benzoquinone, idebenone. Idebenone inhibited NADH(NADPH)/ADP-Fe3+-dependent lipid peroxidation in canine brain mitochondria and protected against the resulting inactivation of NADH-cytochrome c reductase activity. Idebenone did not affect the activities of succinate oxidase in canine and rat brain mitochondria but suppressed the oxygen consumption in NADH oxidation. This suppression might be related to the inhibition of lipid peroxidation. These results suggest that idebenone functions as an electron carrier in the respiratory chains of brain mitochondria and as an antioxidant against membrane damage caused by lipid peroxidation in brain mitochondria.

Citing Articles

Idebenone: When an antioxidant is not an antioxidant.

Gueven N, Ravishankar P, Eri R, Rybalka E Redox Biol. 2020; 38:101812.

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Anti-Oxidant Drugs: Novelties and Clinical Implications in Cerebellar Ataxias.

Barca E, Emmanuele V, DiMauro S, Toscano A, Quinzii C Curr Neuropharmacol. 2017; 17(1):21-32.

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Evaluating the therapeutic potential of idebenone and related quinone analogues in Leber hereditary optic neuropathy.

Yu-Wai-Man P, Soiferman D, Moore D, Burte F, Saada A Mitochondrion. 2017; 36:36-42.

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Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?.

Jaber S, Polster B J Bioenerg Biomembr. 2014; 47(1-2):111-8.

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