Potential Synergistic Action of 19 Schizophrenia Risk Genes in the Thalamus

Overview

Journal Schizophr Res

Specialty Psychiatry

Date 2016 Sep 21

PMID 27645107

Citations 5

Authors

Edwin A Richard

Elizaveta Khlestova

Roshan Nanu

John E Lisman

Affiliations

Soon will be listed here.

Abstract

A goal of current schizophrenia (SZ) research is to understand how multiple risk genes work together with environmental factors to produce the disease. In schizophrenia, there is elevated delta frequency EEG power in the awake state, an elevation that can be mimicked in rodents by N-methyl-d-aspartate receptor (NMDAR) antagonist action in the thalamus. This thalamic delta can be blocked by dopamine D2 receptor antagonists, agents known to be therapeutic in SZ. Experiments suggest that these oscillations can interfere with brain function and may thus be causal in producing psychosis. Here we evaluate the question of whether well-established schizophrenia risk genes may interact to affect the delta generation process. We identify 19 risk genes that can plausibly work in a synergistic fashion to generate delta oscillations.

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