Gluten-Free Diet Only During Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2016 Sep 20

PMID 27642610

Citations 12

Authors

Julie C Antvorskov

Knud Josefsen

Martin Haupt-Jorgensen

Petra Fundova

David P Funda

Karsten Buschard

Affiliations

Soon will be listed here.

Abstract

Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (p < 0.0001) in the gluten-free group. The islets of Langerhans were less infiltrated (p < 0.001) and the intestinal expression of RORγt (Th17) (p < 0.0001) reduced in mice whose mothers were Gluten-free during pregnancy. Conclusion. A gluten-free diet exclusively during pregnancy efficiently prevents autoimmune diabetes development in offspring and reduces insulitis and intestinal expression of RORγt (Th17).

Citing Articles

Probiotic treatment with viable α-galactosylceramide-producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice.

Hansen C, Jozipovic D, Zachariassen L, Nielsen D, Hansen A, Buschard K J Diabetes. 2024; 16(8):e13593.

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The Impact of Dietary Factors during Pregnancy on the Development of Islet Autoimmunity and Type 1 Diabetes: A Systematic Literature Review.

Johansen V, Josefsen K, Antvorskov J Nutrients. 2023; 15(20).

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Failure to replicate the diabetes alleviating effect of a maternal gluten-free diet in non-obese diabetic mice.

Monsted M, Holm L, Buschard K, Haupt-Jorgensen M PLoS One. 2023; 18(9):e0289258.

PMID: 37682921 PMC: 10490983. DOI: 10.1371/journal.pone.0289258.

A Gluten-Free Diet during Pregnancy and Early Life Increases Short Chain Fatty Acid-Producing Bacteria and Regulatory T Cells in Prediabetic NOD Mice.

Johansen V, Faero D, Buschard K, Kristiansen K, Pociot F, Kiilerich P Cells. 2023; 12(12).

PMID: 37371037 PMC: 10297205. DOI: 10.3390/cells12121567.

The etiology and pathogenesis of type 1 diabetes - A personal, non-systematic review of possible causes, and interventions.

Buschard K Front Endocrinol (Lausanne). 2022; 13:876470.

PMID: 36093076 PMC: 9452747. DOI: 10.3389/fendo.2022.876470.

References

Dall M, Calloe K, Haupt-Jorgensen M, Larsen J, Schmitt N, Josefsen K . Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans. PLoS One. 2013; 8(6):e66474. PMC: 3681969. DOI: 10.1371/journal.pone.0066474. View

Antvorskov J, Fundova P, Buschard K, Funda D . Impact of dietary gluten on regulatory T cells and Th17 cells in BALB/c mice. PLoS One. 2012; 7(3):e33315. PMC: 3302844. DOI: 10.1371/journal.pone.0033315. View

Scott F, Rowsell P, Wang G, Burghardt K, Kolb H, Flohe S . Oral exposure to diabetes-promoting food or immunomodulators in neonates alters gut cytokines and diabetes. Diabetes. 2002; 51(1):73-8. DOI: 10.2337/diabetes.51.1.73. View

Hoorfar J, Scott F, Cloutier H . Dietary plant materials and development of diabetes in the BB rat. J Nutr. 1991; 121(6):908-16. DOI: 10.1093/jn/121.6.908. View

Hansen C, Krych L, Buschard K, Metzdorff S, Nellemann C, Hansen L . A maternal gluten-free diet reduces inflammation and diabetes incidence in the offspring of NOD mice. Diabetes. 2014; 63(8):2821-32. DOI: 10.2337/db13-1612. View

Funda D, Kaas A, Bock T, Tlaskalova-Hogenova H, Buschard K . Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev. 1999; 15(5):323-7. DOI: 10.1002/(sici)1520-7560(199909/10)15:5<323::aid-dmrr53>3.0.co;2-p. View

Norris J, Barriga K, Klingensmith G, Hoffman M, Eisenbarth G, Erlich H . Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA. 2003; 290(13):1713-20. DOI: 10.1001/jama.290.13.1713. View

Auricchio R, Paparo F, Maglio M, Franzese A, Lombardi F, Valerio G . In vitro-deranged intestinal immune response to gliadin in type 1 diabetes. Diabetes. 2004; 53(7):1680-3. DOI: 10.2337/diabetes.53.7.1680. View

Hansen A, Josefsen K, Pedersen C, Buschard K . Neonatal stimulation of beta-cells reduces the incidence and delays the onset of diabetes in a barrier-protected breeding colony of BB rats. Exp Clin Endocrinol. 1993; 101(3):189-93. DOI: 10.1055/s-0029-1211230. View

10.

Andre I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D . Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A. 1996; 93(6):2260-3. PMC: 39783. DOI: 10.1073/pnas.93.6.2260. View

11.

Buschard K . What causes type 1 diabetes? Lessons from animal models. APMIS Suppl. 2011; (132):1-19. DOI: 10.1111/j.1600-0463.2011.02765.x. View

12.

Funda D, Kaas A, Tlaskalova-Hogenova H, Buschard K . Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes. Diabetes Metab Res Rev. 2007; 24(1):59-63. DOI: 10.1002/dmrr.748. View

13.

Antvorskov J, Josefsen K, Engkilde K, Funda D, Buschard K . Dietary gluten and the development of type 1 diabetes. Diabetologia. 2014; 57(9):1770-80. PMC: 4119241. DOI: 10.1007/s00125-014-3265-1. View

14.

Chmiel R, Beyerlein A, Knopff A, Hummel S, Ziegler A, Winkler C . Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes. Acta Diabetol. 2014; 52(3):621-4. DOI: 10.1007/s00592-014-0628-5. View

15.

Lamb M, Frederiksen B, Seifert J, Kroehl M, Rewers M, Norris J . Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes: the Diabetes Autoimmunity Study in the Young. Diabetologia. 2015; 58(9):2027-34. PMC: 4529377. DOI: 10.1007/s00125-015-3657-x. View

16.

Dahlquist G, Blom L, Persson L, Sandstrom A, Wall S . Dietary factors and the risk of developing insulin dependent diabetes in childhood. BMJ. 1990; 300(6735):1302-6. PMC: 1663017. DOI: 10.1136/bmj.300.6735.1302. View

17.

Rozen S, Skaletsky H . Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol. 1999; 132:365-86. DOI: 10.1385/1-59259-192-2:365. View

18.

Antvorskov J, Fundova P, Buschard K, Funda D . Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice. Immunology. 2012; 138(1):23-33. PMC: 3533698. DOI: 10.1111/imm.12007. View

19.

Secondulfo M, Iafusco D, Carratu R, Demagistris L, Sapone A, Generoso M . Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig Liver Dis. 2004; 36(1):35-45. DOI: 10.1016/j.dld.2003.09.016. View

20.

Bazzigaluppi E, Belloni C, Arcovio C, Bonifacio E, Bosi E . Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes. J Clin Endocrinol Metab. 2003; 88(1):162-5. DOI: 10.1210/jc.2002-021177. View