Hepatitis C Virus Double-stranded RNA is the Predominant Form in Human Liver and in Interferon-treated Cells

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2016 Sep 20

PMID 27642141

Citations 5

Authors

Arielle Klepper

Francis J Eng

Erin H Doyle

Ahmed El-Shamy

Adeeb H Rahman

M Isabel Fiel

Gonzalo Carrasco Avino

Moonju Lee

Fei Ye

Sasan Roayaie

Meena B Bansal

Margaret R MacDonald

Thomas D Schiano

Andrea D Branch

Affiliations

Soon will be listed here.

Abstract

Conclusion: HCV dsRNA is the predominant form in the HCV-infected liver and has features of both a PAMP and a genomic reservoir. Interferon treatment increased rather than decreased HCV dsRNA. This unexpected finding suggests that HCV produces dsRNA in response to IFN, potentially to antagonize antiviral defenses. (Hepatology 2017;66:357-370).

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