CD14 Monocyte-derived Galectin-9 Induces Natural Killer Cell Cytotoxicity in Chronic Hepatitis C

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2016 Sep 20

PMID 27640362

Citations 13

Authors

Akira Nishio

Tomohide Tatsumi

Takatoshi Nawa

Takahiro Suda

Teppei Yoshioka

Yoshiki Onishi

Satoshi Aono

Minoru Shigekawa

Hayato Hikita

Ryotaro Sakamori

Daisuke Okuzaki

Takasuke Fukuhara

Yoshiharu Matsuura

Naoki Hiramatsu

Tetsuo Takehara

Affiliations

Soon will be listed here.

Abstract

Conclusion: These results demonstrate that CD14 monocyte-derived Gal-9 increases NK cell cytotoxicity in HCV infection, which might be associated with liver injury and persistent infection. (Hepatology 2017;65:18-31).

Citing Articles

Monocyte-derived Galectin-9 and PD-L1 differentially impair adaptive and innate immune response in chronic HBV infection and their expression remain unaltered after antiviral therapy.

Dey D, Biswas S, Pal S, Nandi S, Khatun N, Jha R Front Immunol. 2024; 15:1474853.

PMID: 39445017 PMC: 11496065. DOI: 10.3389/fimmu.2024.1474853.

Cytokine Response of Natural Killer Cells to Hepatitis B Virus Infection Depends on Monocyte Co-Stimulation.

Kupke P, Brucker J, Wettengel J, Protzer U, Wenzel J, Schlitt H Viruses. 2024; 16(5).

PMID: 38793623 PMC: 11125674. DOI: 10.3390/v16050741.

Mesenchymal stem cells-based therapy in liver diseases.

Han H, Jin W, Li X Mol Biomed. 2022; 3(1):23.

PMID: 35895169 PMC: 9326420. DOI: 10.1186/s43556-022-00088-x.

Blood Levels of Galectin-9, an Immuno-Regulating Molecule, Reflect the Severity for the Acute and Chronic Infectious Diseases.

Iwasaki-Hozumi H, Chagan-Yasutan H, Ashino Y, Hattori T Biomolecules. 2021; 11(3).

PMID: 33804076 PMC: 7998537. DOI: 10.3390/biom11030430.

Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors.

Okoye I, Xu L, Motamedi M, Parashar P, Walker J, Elahi S J Immunother Cancer. 2020; 8(2).

PMID: 33310773 PMC: 7735134. DOI: 10.1136/jitc-2020-001849.