Cerebrovascular Complications of Diabetes: Focus on Cognitive Dysfunction

Overview

Journal Clin Sci (Lond)

Specialties Biochemistry
General Medicine
Science

Date 2016 Sep 17

PMID 27634842

Citations 34

Authors

Trevor Hardigan

Rebecca Ward

Adviye Ergul

Affiliations

Soon will be listed here.

Abstract

The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity-mediated inflammation in neurovascular changes in diabetes.

Citing Articles

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Combination treatment with cilostazol and isosorbide mononitrate attenuates microemboli-mediated vascular cognitive impairment and improves imaging and plasma biomarkers in diabetic rats.

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Diabetes complications and cognitive function in young adults with youth-onset type 1 or type 2 diabetes: the SEARCH for Diabetes in Youth Study.

Shapiro A, Bellatorre A, Dabelea D, Stafford J, DAgostino Jr R, Shah A Pediatr Diabetes. 2024; 2023.

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