Dairy, Calcium, Vitamin D and Ovarian Cancer Risk in African-American Women

Overview

Journal Br J Cancer

Specialty Oncology

Date 2016 Sep 16

PMID 27632371

Citations 19

Authors

Bo Qin

Patricia G Moorman

Anthony J Alberg

Jill S Barnholtz-Sloan

Melissa Bondy

Michele L Cote

Ellen Funkhouser

Edward S Peters

Ann G Schwartz

Paul Terry

Joellen M Schildkraut

Elisa V Bandera

Affiliations

Soon will be listed here.

Abstract

Background: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency.

Methods: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

Results: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049).

Conclusions: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.

Citing Articles

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References

Zheng W, Danforth K, Tworoger S, Goodman M, Arslan A, Patel A . Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010; 172(1):70-80. PMC: 2892541. DOI: 10.1093/aje/kwq118. View

Kaufman F, Kogut M, Donnell G, Goebelsmann U, March C, Koch R . Hypergonadotropic hypogonadism in female patients with galactosemia. N Engl J Med. 1981; 304(17):994-8. DOI: 10.1056/NEJM198104233041702. View

Bertone E, Rosner B, Hunter D, Stampfer M, Speizer F, Colditz G . Dietary fat intake and ovarian cancer in a cohort of US women. Am J Epidemiol. 2002; 156(1):22-31. DOI: 10.1093/aje/kwf008. View

Salazar-Martinez E, Lazcano-Ponce E, Escudero-de Los Rios P, Hernandez-Avila M . Nutritional determinants of epithelial ovarian cancer risk: a case-control study in Mexico. Oncology. 2002; 63(2):151-7. DOI: 10.1159/000063814. View

Boucher B, Cotterchio M, Kreiger N, Nadalin V, Block T, Block G . Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian women. Public Health Nutr. 2006; 9(1):84-93. DOI: 10.1079/phn2005763. View

Suchy F, Brannon P, Carpenter T, Fernandez J, Gilsanz V, Gould J . National Institutes of Health Consensus Development Conference: lactose intolerance and health. Ann Intern Med. 2010; 152(12):792-6. DOI: 10.7326/0003-4819-152-12-201006150-00248. View

Tyfield L, Reichardt J, Croke D, Elsas 2nd L, Strobl W, Kozak L . Classical galactosemia and mutations at the galactose-1-phosphate uridyl transferase (GALT) gene. Hum Mutat. 1999; 13(6):417-30. DOI: 10.1002/(SICI)1098-1004(1999)13:6<417::AID-HUMU1>3.0.CO;2-0. View

Cramer D . Lactase persistence and milk consumption as determinants of ovarian cancer risk. Am J Epidemiol. 1989; 130(5):904-10. DOI: 10.1093/oxfordjournals.aje.a115423. View

Vine M, Ness R, Calingaert B, Schildkraut J, Berchuck A . Types and duration of symptoms prior to diagnosis of invasive or borderline ovarian tumor. Gynecol Oncol. 2001; 83(3):466-71. DOI: 10.1006/gyno.2001.6411. View

10.

Grant W . Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Res. 2012; 32(1):223-36. View

11.

Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B . The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014; 14(5):342-57. DOI: 10.1038/nrc3691. View

12.

Chang E, Lee V, Canchola A, Clarke C, Purdie D, Reynolds P . Diet and risk of ovarian cancer in the California Teachers Study cohort. Am J Epidemiol. 2007; 165(7):802-13. PMC: 2093945. DOI: 10.1093/aje/kwk065. View

13.

Merritt M, Cramer D, Vitonis A, Titus L, Terry K . Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes. Int J Cancer. 2012; 132(5):1114-24. PMC: 3495088. DOI: 10.1002/ijc.27701. View

14.

Webb A . Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006; 92(1):17-25. DOI: 10.1016/j.pbiomolbio.2006.02.004. View

15.

Zhang X, Jiang F, Li P, Li C, Ma Q, Nicosia S . Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clin Cancer Res. 2005; 11(1):323-8. View

16.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

17.

Schildkraut J, Alberg A, Bandera E, Barnholtz-Sloan J, Bondy M, Cote M . A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES). BMC Cancer. 2014; 14:688. PMC: 4182887. DOI: 10.1186/1471-2407-14-688. View

18.

Webb P, Bain C, Purdie D, HARVEY P, Green A . Milk consumption, galactose metabolism and ovarian cancer (Australia). Cancer Causes Control. 1999; 9(6):637-44. DOI: 10.1023/a:1008891714412. View

19.

Fulgoni 3rd V, Nicholls J, Reed A, Buckley R, Kafer K, Huth P . Dairy consumption and related nutrient intake in African-American adults and children in the United States: continuing survey of food intakes by individuals 1994-1996, 1998, and the National Health And Nutrition Examination Survey 1999-2000. J Am Diet Assoc. 2007; 107(2):256-64. DOI: 10.1016/j.jada.2006.11.007. View

20.

Fairfield K, Hunter D, Colditz G, Fuchs C, Cramer D, Speizer F . A prospective study of dietary lactose and ovarian cancer. Int J Cancer. 2004; 110(2):271-7. DOI: 10.1002/ijc.20086. View