Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved Among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2016 Sep 16

PMID 27630233

Citations 10

Authors

Dmitry V Chouljenko

Nithya Jambunathan

Vladimir N Chouljenko

Misagh Naderi

Michal Brylinski

John R Caskey

Konstantin G Kousoulas

Affiliations

Soon will be listed here.

Abstract

Importance: The HSV-1 UL37 protein is conserved among all herpesviruses, functions in both retrograde and anterograde transport of virion capsids, and plays critical roles in cytoplasmic virion envelopment by interacting with gK. We show here that UL37 tyrosine residues conserved among all alphaherpesviruses serve critical roles in cytoplasmic virion envelopment and interactions with gK.

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References

McLauchlan J . The abundance of the herpes simplex virus type 1 UL37 tegument protein in virus particles is closely controlled. J Gen Virol. 1997; 78 ( Pt 1):189-94. DOI: 10.1099/0022-1317-78-1-189. View

Chouljenko V, Iyer A, Chowdhury S, Kim J, Kousoulas K . The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB. J Virol. 2010; 84(17):8596-606. PMC: 2919038. DOI: 10.1128/JVI.00298-10. View

Desai P, Sexton G, Huang E, Person S . Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures. J Virol. 2008; 82(22):11354-61. PMC: 2573249. DOI: 10.1128/JVI.00956-08. View

Watanabe D, Ushijima Y, Goshima F, Takakuwa H, Tomita Y, Nishiyama Y . Identification of nuclear export signal in UL37 protein of herpes simplex virus type 2. Biochem Biophys Res Commun. 2000; 276(3):1248-54. DOI: 10.1006/bbrc.2000.3600. View

Melancon J, Luna R, Foster T, Kousoulas K . Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopment. J Virol. 2004; 79(1):299-313. PMC: 538735. DOI: 10.1128/JVI.79.1.299-313.2005. View

Liu X, Fitzgerald K, Kurt-Jones E, Finberg R, Knipe D . Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proc Natl Acad Sci U S A. 2008; 105(32):11335-9. PMC: 2516262. DOI: 10.1073/pnas.0801617105. View

Zhou Z, Dougherty M, Jakana J, He J, Rixon F, Chiu W . Seeing the herpesvirus capsid at 8.5 A. Science. 2000; 288(5467):877-80. DOI: 10.1126/science.288.5467.877. View

Ko D, Cunningham A, Diefenbach R . The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). J Virol. 2009; 84(3):1397-405. PMC: 2812353. DOI: 10.1128/JVI.01721-09. View

Mettenleiter T . Budding events in herpesvirus morphogenesis. Virus Res. 2004; 106(2):167-80. DOI: 10.1016/j.virusres.2004.08.013. View

10.

Davison A, Eberle R, Ehlers B, Hayward G, McGeoch D, Minson A . The order Herpesvirales. Arch Virol. 2008; 154(1):171-7. PMC: 3552636. DOI: 10.1007/s00705-008-0278-4. View

11.

Chouljenko D, Kim I, Chouljenko V, Subramanian R, Walker J, Kousoulas K . Functional hierarchy of herpes simplex virus 1 viral glycoproteins in cytoplasmic virion envelopment and egress. J Virol. 2012; 86(8):4262-70. PMC: 3318672. DOI: 10.1128/JVI.06766-11. View

12.

Desai P . A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells. J Virol. 2000; 74(24):11608-18. PMC: 112442. DOI: 10.1128/jvi.74.24.11608-11618.2000. View

13.

Ashcroft M, Kubbutat M, Vousden K . Regulation of p53 function and stability by phosphorylation. Mol Cell Biol. 1999; 19(3):1751-8. PMC: 83968. DOI: 10.1128/MCB.19.3.1751. View

14.

Johnson D, Baines J . Herpesviruses remodel host membranes for virus egress. Nat Rev Microbiol. 2011; 9(5):382-94. DOI: 10.1038/nrmicro2559. View

15.

Kim I, Chouljenko V, Walker J, Kousoulas K . Herpes simplex virus 1 glycoprotein M and the membrane-associated protein UL11 are required for virus-induced cell fusion and efficient virus entry. J Virol. 2013; 87(14):8029-37. PMC: 3700202. DOI: 10.1128/JVI.01181-13. View

16.

Rozen R, Sathish N, Li Y, Yuan Y . Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus. J Virol. 2008; 82(10):4742-50. PMC: 2346726. DOI: 10.1128/JVI.02745-07. View

17.

Roberts A, Abaitua F, OHare P, McNab D, Rixon F, Pasdeloup D . Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1. J Virol. 2008; 83(1):105-16. PMC: 2612316. DOI: 10.1128/JVI.01032-08. View

18.

Crooks G, Hon G, Chandonia J, Brenner S . WebLogo: a sequence logo generator. Genome Res. 2004; 14(6):1188-90. PMC: 419797. DOI: 10.1101/gr.849004. View

19.

Newcomb W, Brown J . Structure and capsid association of the herpesvirus large tegument protein UL36. J Virol. 2010; 84(18):9408-14. PMC: 2937621. DOI: 10.1128/JVI.00361-10. View

20.

Lee J, Vittone V, Diefenbach E, Cunningham A, Diefenbach R . Identification of structural protein-protein interactions of herpes simplex virus type 1. Virology. 2008; 378(2):347-54. DOI: 10.1016/j.virol.2008.05.035. View