Pregnancy-driven Cardiovascular Maternal MiR-29 Plasticity in Obesity

Overview

Journal J Med Primatol

Publisher Wiley

Date 2016 Sep 16

PMID 27627870

Citations 2

Authors

N Schlabritz-Loutsevitch

K Apostolakis-Kyrus

R Krutilina

G Hubbard

M Kocak

Z Janjetovic

S Sathanandam

A T Slominski

G Mari

E Dick Jr

Affiliations

Soon will be listed here.

Abstract

Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO.

Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified.

Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03).

Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

Citing Articles

Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring.

Cochrane A, Murphy M, Ozanne S, Giussani D Eur Heart J. 2024; 45(48):5127-5145.

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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b.

Liang S, Sun Y, Li L, Long Y, Wang M, Yang H Cardiovasc Ther. 2022; 2022:7145699.

PMID: 35474714 PMC: 9010150. DOI: 10.1155/2022/7145699.

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