The Emerging Role of Obesity, Diet and Lipid Metabolism in Prostate Cancer

Overview

Journal Future Oncol

Specialty Oncology

Date 2016 Sep 15

PMID 27624840

Citations 37

Authors

Matteo Ferro

Daniela Terracciano

Carlo Buonerba

Giuseppe Lucarelli

Danilo Bottero

Sisto Perdona

Riccardo Autorino

Alessandro Serino

Francesco Cantiello

Rocco Damiano

Iulia Andras

Sabino De Placido

Giuseppe Di Lorenzo

Michele Battaglia

Barbara A Jereczek-Fossa

Vincenzo Mirone

Ottavio de Cobelli

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.

Citing Articles

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