The Dual Role of Tumor Lymphatic Vessels in Dissemination of Metastases and Immune Response Development

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2016 Sep 14

PMID 27622039

Citations 24

Authors

Joanna Stachura

Malgorzata Wachowska

Witold W Kilarski

Esra Guc

Jakub Golab

Angelika Muchowicz

Affiliations

Soon will be listed here.

Abstract

Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).

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References

Rosette C, Roth R, Oeth P, Braun A, Kammerer S, Ekblom J . Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis. 2005; 26(5):943-50. DOI: 10.1093/carcin/bgi070. View

Kashima K, Watanabe M, Satoh Y, Hata J, Ishii N, Aoki Y . Inhibition of lymphatic metastasis in neuroblastoma by a novel neutralizing antibody to vascular endothelial growth factor-D. Cancer Sci. 2012; 103(12):2144-52. PMC: 7659268. DOI: 10.1111/cas.12010. View

Mihaly Z, Sztupinszki Z, Surowiak P, Gyorffy B . A comprehensive overview of targeted therapy in metastatic renal cell carcinoma. Curr Cancer Drug Targets. 2012; 12(7):857-72. PMC: 3434473. DOI: 10.2174/156800912802429265. View

Wachowska M, Osiak A, Muchowicz A, Gabrysiak M, Domagala A, Kilarski W . Investigation of cell death mechanisms in human lymphatic endothelial cells undergoing photodynamic therapy. Photodiagnosis Photodyn Ther. 2016; 14:57-65. DOI: 10.1016/j.pdpdt.2016.02.004. View

Warren A, Brorson H, Borud L, Slavin S . Lymphedema: a comprehensive review. Ann Plast Surg. 2007; 59(4):464-72. DOI: 10.1097/01.sap.0000257149.42922.7e. View

Denkert C, Winzer K, Muller B, Weichert W, Pest S, Kobel M . Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. Cancer. 2003; 97(12):2978-87. DOI: 10.1002/cncr.11437. View

Kanamori M, Suzuki K, Yasuda T, Hori T . CD99-positive soft tissue sarcoma with chromosomal translocation between 1 and 16 and inversion of chromosome 5. Oncol Lett. 2012; 3(6):1213-1215. PMC: 3392573. DOI: 10.3892/ol.2012.641. View

Fletcher A, Malhotra D, Turley S . Lymph node stroma broaden the peripheral tolerance paradigm. Trends Immunol. 2010; 32(1):12-8. PMC: 3163075. DOI: 10.1016/j.it.2010.11.002. View

van Trappen P, Steele D, Lowe D, Baithun S, Beasley N, Thiele W . Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol. 2003; 201(4):544-54. DOI: 10.1002/path.1467. View

10.

Shields J, Emmett M, Dunn D, Joory K, Sage L, Rigby H . Chemokine-mediated migration of melanoma cells towards lymphatics--a mechanism contributing to metastasis. Oncogene. 2006; 26(21):2997-3005. DOI: 10.1038/sj.onc.1210114. View

11.

Norrmen C, Tammela T, Petrova T, Alitalo K . Biological basis of therapeutic lymphangiogenesis. Circulation. 2011; 123(12):1335-51. DOI: 10.1161/CIRCULATIONAHA.107.704098. View

12.

Winger R, Harp C, Chiang M, Sullivan D, Watson R, Weber E . Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease. J Immunol. 2016; 196(4):1443-8. PMC: 4744533. DOI: 10.4049/jimmunol.1501634. View

13.

Steeg P . Cancer biology: emissaries set up new sites. Nature. 2005; 438(7069):750-1. DOI: 10.1038/438750b. View

14.

Schafer Z, Brugge J . IL-6 involvement in epithelial cancers. J Clin Invest. 2007; 117(12):3660-3. PMC: 2096452. DOI: 10.1172/JCI34237. View

15.

Agostinis P, Berg K, Cengel K, Foster T, Girotti A, Gollnick S . Photodynamic therapy of cancer: an update. CA Cancer J Clin. 2011; 61(4):250-81. PMC: 3209659. DOI: 10.3322/caac.20114. View

16.

Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H . Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res. 2013; 73(24):7254-64. PMC: 3947537. DOI: 10.1158/0008-5472.CAN-13-0750. View

17.

Han K, Azar D, Sabri A, Lee H, Jain S, Lee B . Characterization of the interaction between endostatin short peptide and VEGF receptor 3. Protein Pept Lett. 2012; 19(9):969-74. PMC: 3646568. DOI: 10.2174/092986612802084465. View

18.

Li J, Ou Z, Yu S, Gu X, Yang C, Chen A . The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer. Breast Cancer Res Treat. 2011; 131(3):837-48. DOI: 10.1007/s10549-011-1502-6. View

19.

Diaz-Munoz M, Osma-Garcia I, Iniguez M, Fresno M . Cyclooxygenase-2 deficiency in macrophages leads to defective p110γ PI3K signaling and impairs cell adhesion and migration. J Immunol. 2013; 191(1):395-406. DOI: 10.4049/jimmunol.1202002. View

20.

Schmieder R, Hoffmann J, Becker M, Bhargava A, Muller T, Kahmann N . Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer. Int J Cancer. 2013; 135(6):1487-96. PMC: 4277327. DOI: 10.1002/ijc.28669. View