Sarcopenia of Thoracic Muscle Mass is Not a Risk Factor for Survival in Lung Transplant Recipients

Overview

Journal J Thorac Dis

Publisher AME Publishing Company

Specialty Pulmonary Medicine

Date 2016 Sep 14

PMID 27621854

Citations 12

Authors

Seokkee Lee

Hyo Chae Paik

Seok Jin Haam

Chang Young Lee

Kyung Sik Nam

Hee Suk Jung

Young Woo Do

Jee Won Shu

Jin Gu Lee

Affiliations

Soon will be listed here.

Abstract

Background: In lung transplantation (LTx), patients with thoracic muscle sarcopenia may have to require longer to recovery. We measured thoracic muscle volume by using the cross sectional area (CSA) and assessed its effect on early outcomes after LTx.

Methods: A retrospective analysis was conducted to evaluate the effect of thoracic sarcopenia in patients undergoing LTx between January 2010 and July 2015. The lowest CSA quartile (Q1) was defined as sarcopenia.

Results: In total, 109 patients were enrolled. The mean CSA was 58.24±15.82 cm(2). Patients in the highest CSA quartile were more likely to be male (92.6% vs. 17.9%, P<0.001), older (55.2±10.1 vs. 43.2±14.9 years, P=0.001), to have a higher body mass index (BMI) (22.3±4.0 vs. 19.4±3.7 kg/m(2), P=0.007), and to have pulmonary fibrosis (85.2% vs. 35.7%, P=0.003) compared with the lowest CSA quartile. Early outcomes including ventilator support duration [32.9±49.2 vs. 24.5±39.9 days, P= not significant (ns)], intensive care unit (ICU) stay duration (28.4±43.7 vs. 24.4±35.9 days, P= ns) and hospital stay duration (61.4±48.2 vs. 50.8±37.2 days, P= ns) tended to be longer in Q1 than Q4, but the difference was not significant. However, the 1-year survival rate was better in Q1 compared with Q4 (66.6% vs. 46.0%, P=0.04).

Conclusions: Although patients with thoracic sarcopenia seem to require a longer post-operative recovery time after LTx, this does not compromise their early outcomes. By contrast, patients with larger thoracic muscle volume (Q4) showed poorer survival times.

Citing Articles

Sarcopenia Predicts Outcomes After Lung Transplantation in Older Lung Transplant Candidates.

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Radiomics of spinal muscles: toward a radiological biomarker for allograft rejection in lung transplant.

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Computed tomography body composition and clinical outcomes following lung transplantation in cystic fibrosis.

Jennerich A, Downey L, Goss C, Kapnadak S, Pryor J, Ramos K BMC Pulm Med. 2023; 23(1):105.

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Comparison of CT derived body composition at the thoracic T4 and T12 with lumbar L3 vertebral levels and their utility in patients with rectal cancer.

Arayne A, Gartrell R, Qiao J, Baird P, Yeung J BMC Cancer. 2023; 23(1):56.

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Sarcopenia as a Predictor of Short- and Long-Term Outcomes in Patients Surgically Treated for Malignant Pleural Mesothelioma.

Faccioli E, Terzi S, Giraudo C, Zuin A, Modugno A, Labella F Cancers (Basel). 2022; 14(15).

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