Metabolic Interactions with Cancer Epigenetics

Overview

Journal Mol Aspects Med

Specialties Biochemistry
Molecular Biology

Date 2016 Sep 14

PMID 27620316

Citations 30

Authors

Xia Gao

Michael A Reid

Mei Kong

Jason W Locasale

Affiliations

Soon will be listed here.

Abstract

Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.

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