Acute Leukemia in Children: A Review of the Current Indian Data

Overview

Journal South Asian J Cancer

Specialty Oncology

Date 2016 Sep 9

PMID 27606304

Citations 33

Authors

Ramandeep Singh Arora

Brijesh Arora

Affiliations

Soon will be listed here.

Abstract

Acute leukemias are the most common diagnostic group of childhood cancer. This review summarizes the published literature on reported current outcomes of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) from India. Overall survival in ALL ranged from 45% to 81% (commonly >60%) and event-free survival ranged from 41% to 70% (commonly >50%). Outcome data for AML was patchy with varying duration of follow-up, but it can be inferred that 50-80% of treated patients had experienced an event (toxic death, refractory disease or relapse). It is imperative that going forward focus should be on collaborative efforts, which promote treatment of patients on risk-stratified adapted protocols based on local infrastructure, improvement in supportive care and encourage prospective multi-center clinical trials.

Citing Articles

Real time-PCR a diagnostic tool for reporting copy number variation and relative gene-expression changes in pediatric B-cell acute lymphoblastic leukemia-a pilot study.

Sadaqat Z, Joseph S, Verma C, Muni Reddy J, Prakash A, Thomas T Biol Methods Protoc. 2025; 10(1):bpae098.

PMID: 39802454 PMC: 11717350. DOI: 10.1093/biomethods/bpae098.

Efficacy and Safety Profile of Biosimilar Polyethylene Glycol (PEG)-Asparaginase (Asviia) in Patients With Acute Leukemia: A Retrospective Study From Kashmir.

R Guru F, Akhter R, Bashir S, Nisar S, Mir M, Zahir Z Cureus. 2024; 16(11):e73727.

PMID: 39677089 PMC: 11646325. DOI: 10.7759/cureus.73727.

Peripheral Blood Neutrophil Nadir and Time to Platelet Recovery during Induction Chemotherapy: Predictors of Clinical Outcomes and Markers for Optimizing Induction Treatment Intensity in Acute Lymphoblastic Leukemia.

Ramesh R, Aggarwal V, Choudhary A, Basu D, Nair N, Ganesan P Asian Pac J Cancer Prev. 2024; 25(9):3229-3237.

PMID: 39342602 PMC: 11700331. DOI: 10.31557/APJCP.2024.25.9.3229.

Treatment outcomes of pediatrics acute myeloid leukemia (AML) and associated factors in the country's tertiary referral hospital, Ethiopia.

Mamo W, Moges A, Yesuf S, Mohamedsaid A, Arega G BMC Cancer. 2024; 24(1):640.

PMID: 38789952 PMC: 11127368. DOI: 10.1186/s12885-024-12404-5.

Paediatric oncologists' perspectives on Strategic solutions to develop Integrated Cancer Palliative Care: feedback intervention theory as an explanatory Framework.

Salins N, Rao K, Damani A, Hughes S, Preston N BMC Palliat Care. 2024; 23(1):130.

PMID: 38778373 PMC: 11112766. DOI: 10.1186/s12904-024-01462-y.

References

Howard S, Pedrosa M, Lins M, Pedrosa A, Pui C, Ribeiro R . Establishment of a pediatric oncology program and outcomes of childhood acute lymphoblastic leukemia in a resource-poor area. JAMA. 2004; 291(20):2471-5. DOI: 10.1001/jama.291.20.2471. View

Zwaan C, Kolb E, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R . Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia. J Clin Oncol. 2015; 33(27):2949-62. PMC: 4567700. DOI: 10.1200/JCO.2015.62.8289. View

Kulkarni K, Marwaha R, Trehan A, Bansal D . Survival outcome in childhood ALL: experience from a tertiary care centre in North India. Pediatr Blood Cancer. 2009; 53(2):168-73. DOI: 10.1002/pbc.21897. View

Yadav S, Ramzan M, Lall M, Sachdeva A . Childhood acute lymphoblastic leukemia outcome in India: progress on all fronts. J Pediatr Hematol Oncol. 2012; 34(4):324. DOI: 10.1097/MPH.0b013e3182422ca0. View

Arora R, Pizer B, Eden T . Understanding refusal and abandonment in the treatment of childhood cancer. Indian Pediatr. 2011; 47(12):1005-10. DOI: 10.1007/s13312-010-0172-5. View

Pui C, Yang J, Hunger S, Pieters R, Schrappe M, Biondi A . Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. J Clin Oncol. 2015; 33(27):2938-48. PMC: 4567699. DOI: 10.1200/JCO.2014.59.1636. View

Chen F, Coyle L, Jones B, Pattullo V . Entecavir versus lamivudine for hepatitis B prophylaxis in patients with haematological disease. Liver Int. 2013; 33(8):1203-10. DOI: 10.1111/liv.12154. View

Mukhopadhyay A, Gangopadhyay S, Dasgupta S, Paul S, Mukhopadhyay S, Ray U . Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India. Indian J Med Paediatr Oncol. 2014; 34(4):280-2. PMC: 3932596. DOI: 10.4103/0971-5851.125245. View

Yadav S, Ramzan M, Lall M, Sachdeva A . Pediatric acute myeloid leukemia: final frontier for pediatric oncologists in developing world. Pediatr Hematol Oncol. 2011; 28(8):647-8. DOI: 10.3109/08880018.2011.601435. View

10.

Sondhi V, Sharma A, Taneja M, Arora B, Banavali S . L-asparginase administration reduces white blood cell count and prevents tumor lysis syndrome in children with hyperleukocytic acute lymphoblastic leukemia. Acta Haematol. 2014; 133(1):6-9. DOI: 10.1159/000358115. View

11.

Hudson M, Meyer W, Pui C . Progress Born From a Legacy of Collaboration. J Clin Oncol. 2015; 33(27):2935-7. DOI: 10.1200/JCO.2015.63.4535. View

12.

Kulkarni K, Arora R, Marwaha R . Survival outcome of childhood acute lymphoblastic leukemia in India: a resource-limited perspective of more than 40 years. J Pediatr Hematol Oncol. 2011; 33(6):475-9. DOI: 10.1097/MPH.0b013e31820e7361. View

13.

Abboud M, Ghanem K, Muwakkit S . Acute lymphoblastic leukemia in low and middle-income countries: disease characteristics and treatment results. Curr Opin Oncol. 2014; 26(6):650-5. DOI: 10.1097/CCO.0000000000000125. View

14.

Bleyer W . The U.S. pediatric cancer clinical trials programmes: international implications and the way forward. Eur J Cancer. 1997; 33(9):1439-47. DOI: 10.1016/s0959-8049(97)00249-9. View

15.

Arora R, Eden T, Kapoor G . Epidemiology of childhood cancer in India. Indian J Cancer. 2009; 46(4):264-73. DOI: 10.4103/0019-509X.55546. View

16.

Rajendranath R, Veeraiah S, Ramesh A, Sagar T . Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India. South Asian J Cancer. 2014; 3(1):60-5. PMC: 3961872. DOI: 10.4103/2278-330X.126529. View

17.

Bajel A, George B, Mathews V, Viswabandya A, Kavitha M, Srivastava A . Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol. Pediatr Blood Cancer. 2008; 51(5):621-5. DOI: 10.1002/pbc.21671. View

18.

Yeoh A, Tan D, Li C, Hori H, Tse E, Pui C . Management of adult and paediatric acute lymphoblastic leukaemia in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013. Lancet Oncol. 2013; 14(12):e508-23. PMC: 4059516. DOI: 10.1016/S1470-2045(13)70452-2. View

19.

Stiller C, Parkin D . Geographic and ethnic variations in the incidence of childhood cancer. Br Med Bull. 1996; 52(4):682-703. DOI: 10.1093/oxfordjournals.bmb.a011577. View

20.

Ablett S, Pinkerton C . Recruiting children into cancer trials--role of the United Kingdom Children's Cancer Study Group (UKCCSG). Br J Cancer. 2003; 88(11):1661-5. PMC: 2377132. DOI: 10.1038/sj.bjc.6600990. View