Alloimmunization in Multitransfused Liver Disease Patients: Impact of Underlying Disease

Overview

Journal Asian J Transfus Sci

Specialty Hematology

Date 2016 Sep 9

PMID 27605851

Citations 2

Authors

Meenu Bajpai

Shruti Gupta

Priyanka Jain

Affiliations

Soon will be listed here.

Abstract

Introduction: Transfusion support is vital to the management of patients with liver diseases. Repeated transfusions are associated with many risks such as transfusion-transmitted infection, transfusion immunomodulation, and alloimmunization.

Materials And Methods: A retrospective data analysis of antibody screening and identification was done from February 2012 to February 2014 to determine the frequency and specificity of irregular red-cell antibodies in multitransfused liver disease patients. The clinical and transfusion records were reviewed. The data was compiled, statistically analyzed, and reviewed.

Results: A total of 842 patients were included in our study. Alloantibodies were detected in 5.22% of the patients. Higher rates of alloimmunization were seen in patients with autoimmune hepatitis, cryptogenic liver disease, liver damage due to drugs/toxins, and liver cancer patients. Patients with alcoholic liver disease had a lower rate of alloimmunization. The alloimmunization was 12.7% (23/181) in females and 3.17% (21/661) in males. Antibodies against the Rh system were the most frequent with 27 of 44 alloantibodies (61.36%). The most common alloantibody identified was anti-E (11/44 cases, 25%), followed by anti-C (6/44 cases, 13.63%).

Conclusion: Our findings suggest that alloimmunization rate is affected by underlying disease. Provision of Rh and Kell phenotype-matched blood can significantly reduce alloimmunization.

Citing Articles

Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang.

Nahendran P, Budin S, Mohd Saat N, Yusop M, Yazid T, Anuar N Asian J Transfus Sci. 2025; 18(2):286-290.

PMID: 39822667 PMC: 11734796. DOI: 10.4103/ajts.ajts_75_22.

Red Blood Cell Alloimmunization and Its Associated Factors among Chronic Liver Disease Patients in a Teaching Hospital in Northeastern Malaysia.

S Abdullah S, Hassan M, Ramli M, Abdullah M, Noor N Diagnostics (Basel). 2023; 13(5).

PMID: 36900030 PMC: 10001194. DOI: 10.3390/diagnostics13050886.

Red Blood Cell Alloimmunization in Korean Patients With Myelodysplastic Syndrome and Liver Cirrhosis.

Kim H, Cho E, Chun S, Kim K, Cho D Ann Lab Med. 2018; 39(2):218-222.

PMID: 30430787 PMC: 6240531. DOI: 10.3343/alm.2019.39.2.218.

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