Association Between Diverticular Disease and Ehlers-Danlos Syndrome: a 13-year Nationwide Population-based Cohort Study

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2016 Sep 9

PMID 27604811

Citations 5

Authors

Julie Leganger

Marie-Louise Kulas Soborg

Laura Quitzau Mortensen

Rasmus Gregersen

Jacob Rosenberg

Jakob Burcharth

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort.

Methods: This nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated.

Results: We identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts.

Conclusions: Patients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.

Citing Articles

Understanding the Natural History of the Disease.

Maguire L Semin Colon Rectal Surg. 2021; 32(1).

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Colonic Diverticulosis. Is there a Genetic Component?.

Miulescu A Maedica (Bucur). 2020; 15(1):105-110.

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Solitary Cecal Diverticulitis Mimicking Acute Appendicitis in a Child: Intraoperative Diagnosis.

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Sampling strategies for selecting general population comparison cohorts.

Heide-Jorgensen U, Adelborg K, Kahlert J, Sorensen H, Pedersen L Clin Epidemiol. 2018; 10:1325-1337.

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Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.

Maguire L, Handelman S, Du X, Chen Y, Pers T, Speliotes E Nat Genet. 2018; 50(10):1359-1365.

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