Association Between MTHFR C677T Polymorphism and Abdominal Aortic Aneurysm Risk: A Comprehensive Meta-analysis with 10,123 Participants Involved

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2016 Sep 8

PMID 27603386

Citations 2

Authors

Jie Liu

Xin Jia

Haifeng Li

Senhao Jia

Minhong Zhang

Yongle Xu

Xin Du

Nianrong Zhang

Weihang Lu

Wei Guo

Affiliations

Soon will be listed here.

Abstract

Background: Abdominal aortic aneurysm (AAA) is a life-threatening condition. A number of studies reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and AAA risk, but substantial controversial findings were observed and the strength of the association remains unclear.

Objective: The aim of this study was to investigate the aforementioned association in the overall population and different subgroups.

Methods: PUBMED and EMBASE databases were searched until March 2016 to identify eligible studies, restricted to humans and articles published in English. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to AAA. Subgroup meta-analyses were conducted on features of the population, such as ethnicity, sex of the participants, and study design (source of control).

Results: Twelve case-control studies on MTHFR C677T polymorphism and AAA risk, including 3555 cases and 6568 case-free controls were identified. The results revealed no significant association between the MTHFR C677T polymorphism and AAA risk in the overall population and within Caucasian or Asian subpopulations in all 5 genetic models. Further subgroup meta-analysis indicated that significantly increased risks were observed among cases with a mean age <70 years (OR = 1.73, 95% CI = 1.10-2.12, P = 0.02), cases with prevalence of smoking <60% (OR = 1.39, 95% CI = 1.02-1.90, P = 0.04), and cases with aneurysm diameter ≥55 mm (OR = 1.55, 95% CI = 1.07-2.24, P = 0.02) in the dominant genetic model. No publication bias was detected in the present study.

Conclusion: In conclusion, our comprehensive meta-analysis suggests that the MTHFR C677T polymorphism may play an important role in AAA susceptibility, especially in younger, non-smoking, larger AAA-diameter subgroups of patients.

Citing Articles

Comparison of Genes Associated with Thoracic and Abdominal Aortic Aneurysms.

Gyftopoulos A, Ziganshin B, Elefteriades J, Ochoa Chaar C Aorta (Stamford). 2023; 11(3):125-134.

PMID: 37279787 PMC: 10449569. DOI: 10.1055/s-0043-57266.

Genetic and Epigenetic Regulation of Aortic Aneurysms.

Kim H, Stansfield B Biomed Res Int. 2017; 2017:7268521.

PMID: 28116311 PMC: 5237727. DOI: 10.1155/2017/7268521.

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