New Strategy for Sepsis: Targeting a Key Role of Platelet-neutrophil Interaction

Overview

Journal Burns Trauma

Publisher Oxford University Press

Date 2016 Sep 8

PMID 27602371

Citations 9

Authors

Xu Wang

Weiting Qin

Bingwei Sun

Affiliations

Soon will be listed here.

Abstract

Neutrophil and platelet are essential arms of the innate immune response. In sepsis, platelet abnormal activation as well as neutrophil paralysis are well recognized. For platelet, it is characterized by the contribution to disseminated intravascular coagulation (DIC) and the enhanced inflammation response. In terms of neutrophil, its dysfunction is manifested by the impaired recruitment and migration to the infectious foci, abnormal sequestration in the remote organs, and the delayed clearance. More recently, it has been apparent that together platelet-neutrophil interaction can induce a faster and harder response during sepsis. This article focuses on the activation of platelet, dysfunction of neutrophil, and the interaction between them during sepsis and profiles some of the molecular mechanisms and outcomes in these cellular dialogues, providing a novel strategy for treatment of sepsis.

Citing Articles

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