Effect of Pregnancy-specific β1-glycoprotein on Indoleamine-2,3-dioxygenase Activity in Human Monocytes

Overview

Journal Dokl Biol Sci

Specialty Biology

Date 2016 Sep 7

PMID 27595833

Citations 1

Authors

S A Zamorina

V P Timganova

M S Bochkova

P V Khramtsov

M B Raev

Affiliations

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Abstract

The role of heterogenic human pregnancy-specific glycoprotein (PSG), obtained by the authors' technology, in the regulation of the indoleamine-2,3-dioxygenase (IDO) activity in female blood monocytes has been studied in vitro. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-γ. Upon the induction of cell proliferation by lipopolysaccharides, the stimulating effect was obtained only with 10 μg/mL of PSG. Enhanced IDO activity is probably a factor of peripheral immunological tolerance and antimicrobial protection against intracellular infections in the gestation period.

Citing Articles

The effects of human pregnancy-specific β1-glycoprotein preparation on Th17 polarization of CD4 cells and their cytokine profile.

Timganova V, Zamorina S, Litvinova L, Todosenko N, Bochkova M, Khramtsov P BMC Immunol. 2020; 21(1):56.

PMID: 33126863 PMC: 7602336. DOI: 10.1186/s12865-020-00385-6.

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