Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2016 Sep 6

PMID 27595112

Citations 2

Authors

Jennifer C Harvey

Bruno T Roseguini

Benjamin M Goerger

Elizabeth A Fallon

Brett J Wong

Affiliations

Soon will be listed here.

Abstract

We tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Participants wore a water-perfused suit perfused with 33°C (control and HFM) or 50°C (HFM + TT) water. Participants consumed 1 g fat/kg body weight. Blood samples were taken at baseline and two hours post-HFM. Blood pressure was measured every 5-10 minutes. Microvascular function was assessed via skin local heating from 33°C to 39°C two hours after HFM. Cutaneous vascular conductance (CVC) was calculated and normalized to maximal vasodilation (%CVCmax). HFM had no effect on initial peak (48 ± 4 %CVCmax) compared to control (49 ± 4 %CVCmax) but attenuated the plateau (51 ± 4 %CVCmax) compared to control (63 ± 4 %CVCmax, P < 0.001). Initial peak was augmented in HFM + TT (66 ± 4 %CVCmax) compared to control and HFM (P < 0.05), while plateau (73 ± 3 % CVCmax) was augmented only compared to the HFM trial (P < 0.001). These data suggest that HFM negatively affects cutaneous vasodilation but can be minimized by TT.

Citing Articles

Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status.

Maranhao P, DE Souza M, Panazzolo D, Nogueira Neto J, Bouskela E, Kraemer-Aguiar L Biomed Res Int. 2018; 2018:5046508.

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Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review.

Hussain J, Cohen M Evid Based Complement Alternat Med. 2018; 2018:1857413.

PMID: 29849692 PMC: 5941775. DOI: 10.1155/2018/1857413.

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