Fabrication of Magnetic and Fluorescent Chitin and Dibutyrylchitin Sub-micron Particles by Oil-in-water Emulsification

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2016 Sep 6

PMID 27592817

Citations 2

Authors

Barbara Blanco-Fernandez

Shatadru Chakravarty

Michael K Nkansah

Erik M Shapiro

Affiliations

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Abstract

Statement Of Significance: We describe a technique to prepare sub-micron particles of highly acetylated chitin (>90%) and dibutyrylchitin and demonstrate their utility as carriers for imaging. Chitin is a polysaccharide capable of stimulating the immune system, a property that depends on the acetamide groups, but its insolubility limits its use. No method for sub-micron particle preparation with highly acetylated chitins have been published. The only approach for the preparation of sub-micron particles uses low acetylation chitins. Dibutyrylchitin, a soluble chitin derivative, was used to prepare particles by oil in water emulsification. Butyryl groups were then removed, forming chitin particles. These particles could be suitable for encapsulation of hydrophobic payloads for drug delivery and cell imaging, as well as, adjuvants for vaccines.

Citing Articles

Complex Relationship Between Iron Oxide Nanoparticle Degradation and Signal Intensity in Magnetic Particle Imaging.

Guzy J, Chakravarty S, Buchanan F, Chen H, Gaudet J, Hix J ACS Appl Nano Mater. 2020; 3(5):3991-3999.

PMID: 33163909 PMC: 7643918. DOI: 10.1021/acsanm.0c00779.

Tantalum oxide nanoparticles as versatile contrast agents for X-ray computed tomography.

Chakravarty S, Hix J, Wiewiora K, Volk M, Kenyon E, Shuboni-Mulligan D Nanoscale. 2020; 12(14):7720-7734.

PMID: 32211669 PMC: 7185737. DOI: 10.1039/d0nr01234c.

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