Liposarcoma: Multimodality Management and Future Targeted Therapies

Overview

Journal Surg Oncol Clin N Am

Specialties General Surgery
Oncology

Date 2016 Sep 4

PMID 27591497

Citations 78

Authors

Aimee M Crago

Mark A Dickson

Affiliations

Soon will be listed here.

Abstract

There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.

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