Prevention of Glucocorticoid-induced Osteopenia: Effect of Oral 25-hydroxyvitamin D and Calcium

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 1989 Jun 1

PMID 2758767

Citations 12

Authors

O Di Munno

F Beghe

P Favini

P Di Giuseppe

A Pontrandolfo

G Occhipinti

G Pasero

Affiliations

Soon will be listed here.

Abstract

Twenty-four patients (9 M and 15 F, age range 51-82) with polymyalgia rheumatica receiving 6-methylprednisolone for a period of 9 months (16 mg/daily/two weeks, 14 mg/daily/two weeks, 12 mg/daily/1 month, 10 mg/daily/1 month, 8 mg/daily/1 month, 6 mg/daily/1 month and 4 mg/daily for the last four months) were randomly assigned to receive either 250HD3 (35 mcg/day for 25 days/month) (Group A) or placebo (Group B) in a double-blind study. All patients also received 500 mg elemental calcium daily. Before and at 3, 6 and 9 months ESR, tenderness on palpation and subjective pain were evaluated. At the same times, mineral metabolism parameters (serum calcium, phosphorus, alkaline phosphatase, 24-h urinary calcium, phosphate and 24-h hydroxyproline excretion) and radial bone mineral content (BMC) were evaluated. Activity indexes (ESR and clinical parameters) improved in both groups. Furthermore, serum alkaline phosphatase and 24-h hydroxyproline excretion decreased significantly only in Group A, and BMC decreased significantly in Group B but rose slightly in Group A. No side effects were observed in any of the patients.

Citing Articles

Vitamin D and Muscle Status in Inflammatory and Autoimmune Rheumatic Diseases: An Update.

Hysa E, Gotelli E, Campitiello R, Paolino S, Pizzorni C, Casabella A Nutrients. 2024; 16(14).

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Prevention and Treatment of Glucocorticoid-Induced Osteoporosis in Adults: Consensus Recommendations From the Belgian Bone Club.

Laurent M, Goemaere S, Verroken C, Bergmann P, Body J, Bruyere O Front Endocrinol (Lausanne). 2022; 13:908727.

PMID: 35757436 PMC: 9219603. DOI: 10.3389/fendo.2022.908727.

Patient-reported outcomes in trials of patients with polymyalgia rheumatica: a systematic literature review.

Huang A, Castrejon I Rheumatol Int. 2016; 36(7):897-904.

PMID: 26769433 DOI: 10.1007/s00296-015-3416-9.

Vitamin D for the treatment of chronic painful conditions in adults.

Straube S, Derry S, Straube C, Moore R Cochrane Database Syst Rev. 2015; (5):CD007771.

PMID: 25946084 PMC: 6494161. DOI: 10.1002/14651858.CD007771.pub3.

Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States.

Shipton E, Shipton E Pain Ther. 2015; 4(1):67-87.

PMID: 25920326 PMC: 4470966. DOI: 10.1007/s40122-015-0036-8.

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