Colistin-resistant Escherichia Coli Clinical Isolate Harbouring the Mcr-1 Gene in Ecuador

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2016 Sep 3

PMID 27586373

Citations 22

Authors

D Ortega-Paredes

P Barba

J Zurita

Affiliations

Soon will be listed here.

Abstract

Colistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male with acute appendicitis, and subjected to molecular analysis. The minimum inhibitory concentration of colistin for the strain was 8 mg/ml and it was susceptible to carbapenems but resistant to tigecycline. The strain harboured mcr-1 and bla CTX-M-55 genes and was of sequence type 609. The recognition of an apparently commensal strain of E. coli harbouring mcr-1 serves as an alert to the presence in the region of this recently described resistance mechanism to one of the last line of drugs available for the treatment of multi-resistant Gram-negative infections.

Citing Articles

Genomic Insights into Colistin and Tigecycline Resistance in ESBL-Producing and Harboring Genes in Ecuador.

Ortega-Paredes D, Del Canto F, Rios R, Diaz L, Reyes J, Arias C Antibiotics (Basel). 2025; 14(2).

PMID: 40001449 PMC: 11851850. DOI: 10.3390/antibiotics14020206.

Detection of mobile colistin resistance genes and in from Ecuadorian children.

Cifuentes S, Graham J, Trueba G, Cadenas P Microbiol Resour Announc. 2024; 13(9):e0031324.

PMID: 39162443 PMC: 11384748. DOI: 10.1128/mra.00313-24.

Molecular epidemiology of carbapenem-resistant gram-negative bacilli in Ecuador.

Soria-Segarra C, Soria-Segarra C, Molina-Matute M, Agreda-Orellana I, Nunez-Quezada T, Cevallos-Apolo K BMC Infect Dis. 2024; 24(1):378.

PMID: 38582858 PMC: 10998298. DOI: 10.1186/s12879-024-09248-6.

Detection of Plasmid-Mediated Resistance against Colistin in Multi-Drug-Resistant Gram-Negative Bacilli Isolated from a Tertiary Hospital.

Galindo-Mendez M, Navarrete-Salazar H, Pacheco-Vasquez R, Quintas-de la Paz D, Baltazar-Jimenez I, Santiago-Luna J Microorganisms. 2023; 11(8).

PMID: 37630556 PMC: 10458375. DOI: 10.3390/microorganisms11081996.

Risk factors associated with colistin resistance in carbapenemase-producing Enterobacterales: a multicenter study from a low-income country.

Claudia S, Carmen S, Andres D, Marcela M, Kerly C, Bryan B Ann Clin Microbiol Antimicrob. 2023; 22(1):64.

PMID: 37533063 PMC: 10398925. DOI: 10.1186/s12941-023-00609-8.

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