Acute-phase Proteins and Incidence of Diabetes: a Population-based Cohort Study

Overview

Journal Acta Diabetol

Specialty Endocrinology

Date 2016 Sep 2

PMID 27581604

Citations 14

Authors

Iram Faqir Muhammad

Yan Borne

Bo Hedblad

Peter M Nilsson

Margaretha Persson

Gunnar Engstrom

Affiliations

Soon will be listed here.

Abstract

Aims: To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CC).

Methods: The study population consists of 4246 participants (aged 46-67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins.

Results: During a mean follow-up period of 15.6 ± 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83-1.67; p = 0.51), 1.19 (CI: 0.85-1.62; p = 0.10), and 1.40 (CI: 1.01-1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively.

Conclusion: The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.

Citing Articles

Effects of Semaglutide and Empagliflozin on Inflammatory Markers in Patients with Type 2 Diabetes.

Reppo I, Jakobson M, Volke V Int J Mol Sci. 2023; 24(6).

PMID: 36982786 PMC: 10054691. DOI: 10.3390/ijms24065714.

The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D.

Speelman T, Dale L, Louw A, Verhoog N Cells. 2022; 11(14).

PMID: 35883605 PMC: 9321356. DOI: 10.3390/cells11142163.

Triglyceride-Glucose Index is a Risk Marker of Incident COPD Events in Women.

Zaigham S, Tanash H, Nilsson P, Muhammad I Int J Chron Obstruct Pulmon Dis. 2022; 17:1393-1401.

PMID: 35746923 PMC: 9212790. DOI: 10.2147/COPD.S360793.

Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort.

Azzouz M, Xu Y, Barregard L, Fagerberg B, Zoller B, Molnar P Environ Health. 2022; 21(1):39.

PMID: 35413834 PMC: 9004064. DOI: 10.1186/s12940-022-00851-1.

Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort.

Muhammad I, Borne Y, Zaigham S, Soderholm M, Johnson L, Persson M BMC Cardiovasc Disord. 2021; 21(1):536.

PMID: 34772344 PMC: 8588679. DOI: 10.1186/s12872-021-02344-4.

References

Hotamisligil G . The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med. 1999; 245(6):621-5. DOI: 10.1046/j.1365-2796.1999.00490.x. View

Melander O, Maisel A, Almgren P, Manjer J, Belting M, Hedblad B . Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality. JAMA. 2012; 308(14):1469-75. DOI: 10.1001/jama.2012.12998. View

Hotamisligil G, Shargill N, Spiegelman B . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993; 259(5091):87-91. DOI: 10.1126/science.7678183. View

Dandona P, Weinstock R, Thusu K, Abdel-Rahman E, Aljada A, Wadden T . Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab. 1998; 83(8):2907-10. DOI: 10.1210/jcem.83.8.5026. View

Li C, Aronsson C, Hedblad B, Gullberg B, Wirfalt E, Berglund G . Ability of physical activity measurements to assess health-related risks. Eur J Clin Nutr. 2009; 63(12):1448-51. DOI: 10.1038/ejcn.2009.69. View

Ludvigsson J, Andersson E, Ekbom A, Feychting M, Kim J, Reuterwall C . External review and validation of the Swedish national inpatient register. BMC Public Health. 2011; 11:450. PMC: 3142234. DOI: 10.1186/1471-2458-11-450. View

Engstrom G, Hedblad B, Eriksson K, Janzon L, Lindgarde F . Complement C3 is a risk factor for the development of diabetes: a population-based cohort study. Diabetes. 2005; 54(2):570-5. DOI: 10.2337/diabetes.54.2.570. View

Ghanim H, Abuaysheh S, Sia C, Korzeniewski K, Chaudhuri A, Fernandez-Real J . Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care. 2009; 32(12):2281-7. PMC: 2782991. DOI: 10.2337/dc09-0979. View

Schmidt M, Duncan B, Sharrett A, Lindberg G, Savage P, Offenbacher S . Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet. 1999; 353(9165):1649-52. DOI: 10.1016/s0140-6736(99)01046-6. View

10.

Brunner E, Kivimaki M, Witte D, Lawlor D, Davey Smith G, Cooper J . Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoS Med. 2008; 5(8):e155. PMC: 2504484. DOI: 10.1371/journal.pmed.0050155. View

11.

Berglund G, Elmstahl S, Janzon L, Larsson S . The Malmo Diet and Cancer Study. Design and feasibility. J Intern Med. 1993; 233(1):45-51. DOI: 10.1111/j.1365-2796.1993.tb00647.x. View

12.

Engstrom G, Hedblad B, Stavenow L, Lind P, Janzon L, Lindgarde F . Inflammation-sensitive plasma proteins are associated with future weight gain. Diabetes. 2003; 52(8):2097-101. DOI: 10.2337/diabetes.52.8.2097. View

13.

McMillan D . Increased levels of acute-phase serum proteins in diabetes. Metabolism. 1989; 38(11):1042-6. DOI: 10.1016/0026-0495(89)90038-3. View

14.

Hedblad B, Nilsson P, Janzon L, Berglund G . Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmö, Sweden. Diabet Med. 2000; 17(4):299-307. DOI: 10.1046/j.1464-5491.2000.00280.x. View

15.

Bode J, Albrecht U, Haussinger D, Heinrich P, Schaper F . Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling. Eur J Cell Biol. 2011; 91(6-7):496-505. DOI: 10.1016/j.ejcb.2011.09.008. View

16.

Fiorentino T, Hribal M, Perticone M, Andreozzi F, Sciacqua A, Perticone F . Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria. Acta Diabetol. 2014; 52(2):349-56. DOI: 10.1007/s00592-014-0647-2. View

17.

Festa A, DAgostino Jr R, Tracy R, Haffner S . Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes. 2002; 51(4):1131-7. DOI: 10.2337/diabetes.51.4.1131. View

18.

Oda E . High-sensitivity C-reactive protein, but not white blood cell count, independently predicted incident diabetes in a Japanese health screening population. Acta Diabetol. 2015; 52(5):983-90. DOI: 10.1007/s00592-015-0788-y. View

19.

Moshage H . Cytokines and the hepatic acute phase response. J Pathol. 1997; 181(3):257-66. DOI: 10.1002/(SICI)1096-9896(199703)181:3<257::AID-PATH756>3.0.CO;2-U. View

20.

Hotamisligil G, Peraldi P, Budavari A, Ellis R, White M, Spiegelman B . IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science. 1996; 271(5249):665-8. DOI: 10.1126/science.271.5249.665. View