D1, but Not D2, Receptor Blockade Within the Infralimbic and Medial Orbitofrontal Cortex Impairs Cocaine Seeking in a Region-specific Manner

Overview

Journal Addict Biol

Specialty Psychiatry

Date 2016 Sep 1

PMID 27578356

Citations 9

Authors

Caitlin V Cosme

Andrea L Gutman

Wensday R Worth

Ryan T LaLumiere

Affiliations

Soon will be listed here.

Abstract

Evidence suggests that the infralimbic cortex (IL), a subregion of the ventromedial prefrontal cortex (vmPFC), suppresses cocaine-seeking behavior in a self-administration paradigm, whereas the more anterior vmPFC subregion, the medial orbitofrontal cortex (mOFC), has received very little attention in this regard. Despite the established dopaminergic innervation of the vmPFC, whether dopamine receptor blockade in each subregion alters the reinstatement of cocaine seeking is unclear. To address this issue, male Sprague-Dawley rats underwent 2 weeks of cocaine self-administration, followed by extinction training and reinstatement testing. Immediately prior to each reinstatement test, rats received microinjections of the D1 receptor antagonist SCH 23390, the D2 receptor antagonist sulpiride or their respective vehicles. D1 receptor blockade in the IL reduced cued reinstatement but had no effect on cocaine prime and cue + cocaine-prime reinstatement, whereas D2 receptor blockade in the IL had no effect on reinstatement. For the mOFC, however, D1 receptor blockade reduced cocaine seeking in all reinstatement types, whereas blocking D2 receptors in the mOFC had no effect on any form of cocaine seeking. These findings suggest different roles for D1 receptors in the IL versus the mOFC in regulating cocaine-seeking behavior. Moreover, even as previous work indicates that IL inactivation does not affect reinstatement but, rather, induces cocaine seeking during extinction, the present findings suggest that dopamine receptor activation in the IL is necessary for cocaine seeking under some circumstances.

Citing Articles

Medial orbitofrontal cortical regulation of different aspects of Pavlovian and instrumental reward seeking.

Jenni N, Symonds N, Floresco S Psychopharmacology (Berl). 2022; 240(3):441-459.

PMID: 36322185 DOI: 10.1007/s00213-022-06265-8.

Abstinence-Dependent Effects of Long-Access Cocaine Self-Administration on Nucleus Accumbens Astrocytes Are Observed in Male, But Not Female, Rats.

Kim R, Testen A, Harder E, Brown N, Witt E, Bellinger T eNeuro. 2022; 9(5).

PMID: 35995558 PMC: 9491344. DOI: 10.1523/ENEURO.0310-22.2022.

Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.

Kawahara Y, Ohnishi Y, Ohnishi Y, Kawahara H, Nishi A Int J Neuropsychopharmacol. 2021; 24(12):988-1001.

PMID: 34626116 PMC: 8653875. DOI: 10.1093/ijnp/pyab067.

Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?.

Nett K, LaLumiere R Neurosci Biobehav Rev. 2021; 131:704-721.

PMID: 34624366 PMC: 8642304. DOI: 10.1016/j.neubiorev.2021.10.002.

Medial orbitofrontal cortex dopamine D/D receptors differentially modulate distinct forms of probabilistic decision-making.

Jenni N, Li Y, Floresco S Neuropsychopharmacology. 2021; 46(7):1240-1251.

PMID: 33452435 PMC: 8134636. DOI: 10.1038/s41386-020-00931-1.

References

Smiley J, Williams S, Szigeti K, Goldman-Rakic P . Light and electron microscopic characterization of dopamine-immunoreactive axons in human cerebral cortex. J Comp Neurol. 1992; 321(3):325-35. DOI: 10.1002/cne.903210302. View

Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O . Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature. 1997; 385(6617):634-6. DOI: 10.1038/385634a0. View

Pakdel R, Rashidy-Pour A . Microinjections of the dopamine D2 receptor antagonist sulpiride into the medial prefrontal cortex attenuate glucocorticoid-induced impairment of long-term memory retrieval in rats. Neurobiol Learn Mem. 2006; 87(3):385-90. DOI: 10.1016/j.nlm.2006.10.002. View

Hitchcott P, Quinn J, Taylor J . Bidirectional modulation of goal-directed actions by prefrontal cortical dopamine. Cereb Cortex. 2007; 17(12):2820-7. DOI: 10.1093/cercor/bhm010. View

Hoover W, Vertes R . Projections of the medial orbital and ventral orbital cortex in the rat. J Comp Neurol. 2011; 519(18):3766-801. DOI: 10.1002/cne.22733. View

Fuchs R, Evans K, Parker M, See R . Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. J Neurosci. 2004; 24(29):6600-10. PMC: 6729870. DOI: 10.1523/JNEUROSCI.1924-04.2004. View

Ishikawa A, Nakamura S . Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat. J Neurosci. 2003; 23(31):9987-95. PMC: 6740854. View

LaLumiere R, Niehoff K, Kalivas P . The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration. Learn Mem. 2010; 17(4):168-75. PMC: 2852618. DOI: 10.1101/lm.1576810. View

Paul M, Graybiel A, David J, Robertson H . D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease. J Neurosci. 1992; 12(10):3729-42. PMC: 6575976. View

10.

Bossert J, Stern A, Theberge F, Cifani C, Koya E, Hope B . Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nat Neurosci. 2011; 14(4):420-2. PMC: 3077927. DOI: 10.1038/nn.2758. View

11.

Sawaguchi T, Goldman-Rakic P . D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science. 1991; 251(4996):947-50. DOI: 10.1126/science.1825731. View

12.

Rogers J, Ghee S, See R . The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse. Neuroscience. 2007; 151(2):579-88. PMC: 2238688. DOI: 10.1016/j.neuroscience.2007.10.012. View

13.

Williams G, Goldman-Rakic P . Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature. 1995; 376(6541):572-5. DOI: 10.1038/376572a0. View

14.

Goldman-Rakic P, Muly 3rd E, Williams G . D(1) receptors in prefrontal cells and circuits. Brain Res Brain Res Rev. 2000; 31(2-3):295-301. DOI: 10.1016/s0165-0173(99)00045-4. View

15.

Peters J, Pattij T, de Vries T . Targeting cocaine versus heroin memories: divergent roles within ventromedial prefrontal cortex. Trends Pharmacol Sci. 2013; 34(12):689-95. DOI: 10.1016/j.tips.2013.10.004. View

16.

Setlow B, McGaugh J . Sulpiride infused into the nucleus accumbens posttraining impairs memory of spatial water maze training. Behav Neurosci. 1998; 112(3):603-10. DOI: 10.1037//0735-7044.112.3.603. View

17.

Lasseter H, Ramirez D, Xie X, Fuchs R . Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats. Eur J Neurosci. 2009; 30(7):1370-81. PMC: 2758926. DOI: 10.1111/j.1460-9568.2009.06906.x. View

18.

Richard J, Berridge K . Prefrontal cortex modulates desire and dread generated by nucleus accumbens glutamate disruption. Biol Psychiatry. 2012; 73(4):360-70. PMC: 3535675. DOI: 10.1016/j.biopsych.2012.08.009. View

19.

Sun W, Rebec G . The role of prefrontal cortex D1-like and D2-like receptors in cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2004; 177(3):315-23. DOI: 10.1007/s00213-004-1956-x. View

20.

Anderson S, Schmidt H, Pierce R . Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology. 2005; 31(7):1452-61. DOI: 10.1038/sj.npp.1300922. View