Simultaneous Microwave Coagulo-necrotic Therapy (MCN) and Laparoscopic Splenectomy for the Treatment of Hepatocellular Carcinoma with Cirrhotic Hypersplenism

Overview

Journal Surg Today

Specialty General Surgery

Date 2016 Sep 1

PMID 27577937

Citations 7

Authors

Tomoki Ryu

Yuko Takami

Norifumi Tsutsumi

Masaki Tateishi

Kazuhiro Mikagi

Yoshiyuki Wada

Hideki Saitsu

Affiliations

Soon will be listed here.

Abstract

Purpose: To establish the efficacy and safety of simultaneous microwave coagulo-necrotic therapy (MCN) and laparoscopic splenectomy (Lap-Sp) for the treatment of hepatocellular carcinoma (HCC) with cirrhotic hypersplenism.

Methods: Seventeen patients with HCC and cirrhotic hypersplenism underwent simultaneous MCN and Lap-Sp at our institution between January, 2010 and July, 2015. Eight and nine patients had Child-Pugh class A and B liver cirrhosis, respectively. The median number of tumors ablated was 1 (range 1-7) and the median largest dimension of the resected lesions was 1.7 cm (range 1.1-3.6 cm). We analyzed postoperative complications and long-term outcomes retrospectively.

Results: The median operating time was 283 min (range 197-418 min) and the median blood loss was 125 mL (range 5-1312 mL). Postoperative morbidity and mortality rates were 29 and 0 %, respectively. The median follow-up time after surgery was 22.5 months (range 4.3-70.9 months). The 1-, 3-, and 5-year disease-free survival rates were 68.8, 10.7, and 10.7 %, respectively, and the 1-, 3-, and 5-year overall survival rates were 88.2, 75.6, and 63.0 %, respectively.

Conclusions: The findings of this study suggest that simultaneous MCN and Lap-Sp is safe and effective for treating HCC with cirrhotic hypersplenism.

Citing Articles

Image-guided locoregional non-intravascular interventional treatments for hepatocellular carcinoma: Current status.

Qian K, Zhang F, Allison S, Zheng C, Yang X J Interv Med. 2021; 4(1):1-7.

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Feasibility and safety of surgical microwave ablation for hepatocellular carcinoma in elderly patients: a single center analysis in Japan.

Imamura H, Takami Y, Ryu T, Wada Y, Sasaki S, Ureshino H Sci Rep. 2020; 10(1):14215.

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Improved survival following splenectomy combined with curative treatments for hepatocellular carcinoma in Child B patients: A propensity score matching study.

Pei Y, Zhang Z, Mbanbo-Koumpa A, Chen X, Zhang W Hepatol Res. 2018; 49(2):177-188.

PMID: 30347506 PMC: 6850487. DOI: 10.1111/hepr.13276.

Prognosis of Hepatocellular Carcinoma Patients Who Achieved Long-Term Recurrence-Free Survival After Curative Therapy: Impact of the ALBI Grade.

Matsushima H, Takami Y, Ryu T, Yoshitomi M, Tateishi M, Wada Y J Gastrointest Surg. 2018; 22(7):1230-1238.

PMID: 29736665 DOI: 10.1007/s11605-018-3745-6.

Effect of achieving sustained virological response before hepatitis C virus-related hepatocellular carcinoma occurrence on survival and recurrence after curative surgical microwave ablation.

Ryu T, Takami Y, Wada Y, Tateishi M, Matsushima H, Yoshitomi M Hepatol Int. 2018; 12(2):149-157.

PMID: 29488056 DOI: 10.1007/s12072-018-9851-4.

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