Upregulated TRIM32 Correlates with Enhanced Cell Proliferation and Poor Prognosis in Hepatocellular Carcinoma

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2016 Aug 31

PMID 27573002

Citations 21

Authors

Xiaopeng Cui

Zhipeng Lin

Yuyan Chen

Xiaofei Mao

Wenkai Ni

Jinxia Liu

Huiling Zhou

Xiaohang Shan

Lingling Chen

Jiale Lv

Zhongyi Shen

Chengwei Duan

Baoying Hu

Runzhou Ni

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and the sixth most prevalent human malignancies worldwide. However, the molecular mechanisms underlying hepatocarcinogenesis remain unclear. For HCC patients, there is not only a lack of effective therapeutic targets but also a lack of predictive or prognostic biomarkers. In this article, we reported that TRIM32 was obviously upregulated in HCC tumor tissues and HCC cell lines. Its expression patterns were positively correlated with histological grade, tumor sizes, and HBsAg of HCC patients. TRIM32 expression was a significant predictor for the overall survival time of HCC patients. Moreover, the overexpression of TRIM32 in cells accelerated the G1-S phase transition, promoted cell proliferation rates, and induced the resistance of HCC patients to oxaliplatin. All these findings suggest that TRIM32 might play important roles in the hepatocarcinogenesis. TRIM32 could be a novel direction to explore the mechanism underlying HCC pathogenesis.

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