Functional Interleukin-33 Receptors Are Expressed in Early Progenitor Stages of Allergy-related Granulocytes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2016 Aug 30

PMID 27568595

Citations 9

Authors

Hirofumi Tsuzuki

Yojiro Arinobu

Kohta Miyawaki

Ayako Takaki

Shun-Ichiro Ota

Yuri Ota

Hiroki Mitoma

Mitsuteru Akahoshi

Yasuo Mori

Hiromi Iwasaki

Hiroaki Niiro

Hiroshi Tsukamoto

Koichi Akashi

Affiliations

Soon will be listed here.

Abstract

Interleukin-33 (IL-33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity-mediated allergic inflammation. Allergy-related innate myeloid cells such as eosinophils, basophils and mast cells express the IL-33 receptor (IL-33R), but it is still unknown how IL-33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL-33R was expressed on eosinophil progenitors (EoPs), basophil progenitors (BaPs) and mast cell progenitors (MCPs). In the presence of IL-33, these progenitors did not expand, but produced a high amount of Th2 and pro-inflammatory cytokines such as IL-9, IL-13, IL-1β and IL-6. The amount of cytokines produced by these progenitors was greater than that by mature cells. In vivo, IL-33 stimulated the expansion of EoPs, but it was dependent upon the elevated serum IL-5 that is presumably derived from type 2 innate lymphoid cells that express functional IL-33R. These data collectively suggest that EoPs, BaPs and MCPs are not only the sources of allergy-related granulocytes, but can also be sources of allergy-related cytokines in IL-33-induced inflammation. Because such progenitors can differentiate into mature granulocytes at the site of inflammation, they are potential therapeutic targets in IL-33-related allergic diseases.

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