Adult Status Epilepticus: A Review of the Prehospital and Emergency Department Management

Overview

Journal J Clin Med

Specialty General Medicine

Date 2016 Aug 27

PMID 27563928

Citations 8

Authors

Michael Billington

Osama R Kandalaft

Imoigele P Aisiku

Affiliations

Soon will be listed here.

Abstract

Seizures are a common presentation in the prehospital and emergency department setting and status epilepticus represents an emergency neurologic condition. The classification and various types of seizures are numerous. The objectives of this narrative literature review focuses on adult patients with a presentation of status epilepticus in the prehospital and emergency department setting. In summary, benzodiazepines remain the primary first line therapeutic agent in the management of status epilepticus, however, there are new agents that may be appropriate for the management of status epilepticus as second- and third-line pharmacological agents.

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References

Dieckmann R . Rectal diazepam therapy for prehospital pediatric status epilepticus. West J Med. 1991; 155(3):287-8. PMC: 1002990. View

Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y . Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012; 366(7):591-600. PMC: 3307101. DOI: 10.1056/NEJMoa1107494. View

Aydin S, Dag E, Ozkan Y, Arslan O, Koc G, Bek S . Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients. Peptides. 2011; 32(6):1276-80. DOI: 10.1016/j.peptides.2011.04.021. View

Spatola M, Novy J, Du Pasquier R, Dalmau J, Rossetti A . Status epilepticus of inflammatory etiology: a cohort study. Neurology. 2015; 85(5):464-70. PMC: 4534074. DOI: 10.1212/WNL.0000000000001717. View

Huff J, Fountain N . Pathophysiology and definitions of seizures and status epilepticus. Emerg Med Clin North Am. 2010; 29(1):1-13. DOI: 10.1016/j.emc.2010.08.001. View

Dunn M, Breen D, Davenport R, Gray A . Early management of adults with an uncomplicated first generalised seizure. Emerg Med J. 2005; 22(4):237-42. PMC: 1726732. DOI: 10.1136/emj.2004.015651. View

Delgado-Escueta A, WASTERLAIN C, Treiman D, Porter R . Current concepts in neurology: management of status epilepticus. N Engl J Med. 1982; 306(22):1337-40. DOI: 10.1056/NEJM198206033062205. View

Coeytaux A, Jallon P, Galobardes B, Morabia A . Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology. 2000; 55(5):693-7. DOI: 10.1212/wnl.55.5.693. View

Wu Y, Shek D, Garcia P, Zhao S, Johnston S . Incidence and mortality of generalized convulsive status epilepticus in California. Neurology. 2002; 58(7):1070-6. DOI: 10.1212/wnl.58.7.1070. View

10.

McArthur 3rd C, Rooke C . Are spinal precautions necessary in all seizure patients?. Am J Emerg Med. 1995; 13(5):512-3. DOI: 10.1016/0735-6757(95)90159-0. View

11.

Navarro V, Dagron C, Elie C, Lamhaut L, Demeret S, Urien S . Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial. Lancet Neurol. 2015; 15(1):47-55. DOI: 10.1016/S1474-4422(15)00296-3. View

12.

Towne A, Pellock J, Ko D, DeLorenzo R . Determinants of mortality in status epilepticus. Epilepsia. 1994; 35(1):27-34. DOI: 10.1111/j.1528-1157.1994.tb02908.x. View

13.

Trinka E, Cock H, Hesdorffer D, Rossetti A, Scheffer I, Shinnar S . A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015; 56(10):1515-23. DOI: 10.1111/epi.13121. View

14.

Nei M, Lee J, Shanker V, Sperling M . The EEG and prognosis in status epilepticus. Epilepsia. 1999; 40(2):157-63. DOI: 10.1111/j.1528-1157.1999.tb02069.x. View

15.

Welch R, Nicholas K, Durkalski-Mauldin V, Lowenstein D, Conwit R, Mahajan P . Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia. 2015; 56(2):254-62. PMC: 4386287. DOI: 10.1111/epi.12905. View

16.

Sutter R, Kaplan P, Ruegg S . Independent external validation of the status epilepticus severity score. Crit Care Med. 2013; 41(12):e475-9. DOI: 10.1097/CCM.0b013e31829eca06. View

17.

Huff J, Melnick E, Tomaszewski C, Thiessen M, Jagoda A, Fesmire F . Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. Ann Emerg Med. 2014; 63(4):437-47.e15. DOI: 10.1016/j.annemergmed.2014.01.018. View

18.

Mayer S, Claassen J, Lokin J, Mendelsohn F, Dennis L, Fitzsimmons B . Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol. 2002; 59(2):205-10. DOI: 10.1001/archneur.59.2.205. View

19.

Koubeissi M, Alshekhlee A . In-hospital mortality of generalized convulsive status epilepticus: a large US sample. Neurology. 2007; 69(9):886-93. DOI: 10.1212/01.wnl.0000269791.96189.70. View

20.

DeGiorgio C, Heck C, Rabinowicz A, Gott P, Smith T, Correale J . Serum neuron-specific enolase in the major subtypes of status epilepticus. Neurology. 1999; 52(4):746-9. DOI: 10.1212/wnl.52.4.746. View