Serum Antibody Levels Against Porphyromonas Gingivalis in Patients with and Without Rheumatoid Arthritis - a Systematic Review and Meta-analysis

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2016 Aug 27

PMID 27561661

Citations 36

Authors

Philip Bender

Walter B Burgin

Anton Sculean

Sigrun Eick

Affiliations

Soon will be listed here.

Abstract

Objectives: Since the peptidyl arginine deiminase of Porphyromonas gingivalis is able to citrullinate peptides and proteins, various studies have suggested the species as a possible link between periodontal disease (PD) and rheumatoid arthritis (RA). This systematic review including meta-analysis was aimed to evaluate whether differences in terms of antibody titers against P. gingivalis exist between RA patients and systemically healthy individuals with and without PD.

Materials And Methods: The following focused question was addressed: Are the antibody titers against P. gingivalis of RA patients different from systemically healthy individuals with and without PD? A systematic data search was conducted in MEDLINE and EMBASE. The collected data underwent a meta-analysis to detect statistically significant differences in terms of antibody levels between the groups.

Results: From 114 articles found by the search 13 articles met the inclusion criteria and provided data suitable for meta-analysis. After analyzing various levels of confinement the meta-analysis revealed a statistically significant higher antibody titer against P. gingivalis in patients suffering from RA in comparison with systemically and periodontally healthy controls (p < 0.01) and systemically healthy patients with PD (p < 0.01).

Conclusion: The present findings indicate that RA is often accompanied by the presence of an immune response against P. gingivalis.

Clinical Relevance: The significantly higher antibody response to P. gingivalis in comparison to systemically healthy individuals supports the link between PD and RA by P. gingivalis. Screening of the regularly taken blood samples of RA patients for P. gingivalis antibodies may help to sensitize rheumatologists and RA patients for improving periodontal health.

Citing Articles

associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population.

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The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity.

Kindstedt E, de Vries C, Wanman M, Potempa B, Potempa J, Lindquist S Front Immunol. 2025; 15:1504975.

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Impact of Periodontal Treatment on Early Rheumatoid Arthritis and the Role of Porphyromonas gingivalis Antibody Titers.

Nakajima Y, Kato-Kogoe N, Yasuda T, Urakawa R, Matsuo T, Omori M Med Sci Monit. 2025; 31:e947146.

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Cannavo A, Babajani N, Saeedian B, Ghondaghsaz E, Rengo S, Khalaji A Clin Exp Dent Res. 2024; 10(6):e70041.

PMID: 39535348 PMC: 11558155. DOI: 10.1002/cre2.70041.

Quantification of using real-time polymerase chain reaction in subjects suffering from chronic periodontitis with and without rheumatoid arthritis.

Bhatsange A, Rajput K J Indian Soc Periodontol. 2024; 28(2):210-215.

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