Genetic Determinants in Head and Neck Squamous Cell Carcinoma and Their Influence on Global Personalized Medicine

Overview

Journal Genes Cancer

Specialty Oncology

Date 2016 Aug 24

PMID 27551333

Citations 28

Authors

Nicole L Michmerhuizen

Andrew C Birkeland

Carol R Bradford

J Chad Brenner

Affiliations

Soon will be listed here.

Abstract

While sequencing studies have provided an improved understanding of the genetic landscape of head and neck squamous cell carcinomas (HNSCC), there remains a significant lack of genetic data derived from non-Caucasian cohorts. Additionally, there is wide variation in HNSCC incidence and mortality worldwide both between and within various geographic regions. These epidemiologic differences are in part accounted for by varying exposure to environmental risk factors such as tobacco, alcohol, high risk human papilloma viruses and betel quid. However, inherent genetic factors may also play an important role in this variability. As limited sequencing data is available for many populations, the involvement of unique genetic factors in HNSCC pathogenesis from epidemiologically diverse groups is unknown. Here, we review current knowledge about the epidemiologic, environmental, and genetic variation in HNSCC cohorts globally and discuss future studies necessary to further our understanding of these differences. Long-term, a more complete understanding of the genetic drivers found in diverse HNSCC cohorts may help the development of personalized medicine protocols for patients with rare or complex genetic events.

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References

McNeil C . NCI-MATCH launch highlights new trial design in precision-medicine era. J Natl Cancer Inst. 2015; 107(7). DOI: 10.1093/jnci/djv193. View

Sok J, Coppelli F, Thomas S, Lango M, Xi S, Hunt J . Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006; 12(17):5064-73. DOI: 10.1158/1078-0432.CCR-06-0913. View

Quon H, Cohen M, Montone K, Ziober A, Wang L, Weinstein G . Transoral robotic surgery and adjuvant therapy for oropharyngeal carcinomas and the influence of p16 INK4a on treatment outcomes. Laryngoscope. 2012; 123(3):635-40. DOI: 10.1002/lary.22172. View

Giuliano A, Nyitray A, Kreimer A, Pierce Campbell C, Goodman M, Sudenga S . EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection. Int J Cancer. 2014; 136(12):2752-60. PMC: 4297584. DOI: 10.1002/ijc.29082. View

Chen S, Liu H, Liao C, Huang P, Huang Y, Hsu A . Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature. Oncotarget. 2015; 6(20):18066-80. PMC: 4621868. DOI: 10.18632/oncotarget.3768. View

Ellisen L, Bird J, West D, Soreng A, Reynolds T, Smith S . TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991; 66(4):649-61. DOI: 10.1016/0092-8674(91)90111-b. View

Ogmundsdottir H, Hilmarsdottir H, Astvaldsdottir A, Johannsson J, Holbrook W . Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in icelanD. Eur J Oral Sci. 2002; 110(3):192-8. DOI: 10.1034/j.1600-0447.2002.21235.x. View

Kostakis G, Papadogeorgakis N, Koumaki V, Kamakari S, Koumaki D, Alexandridis C . Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(5):e53-8. DOI: 10.1016/j.tripleo.2010.01.015. View

Chang Y, Hsu H, Ko Y, Yeh K, Chang S, Lin C . Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 118(1):110-116.e1. DOI: 10.1016/j.oooo.2014.03.016. View

10.

Ren W, Jiang D, Pei Y, Wang S, Yang X, Yu L . Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies. Genet Mol Res. 2014; 13(1):103-14. DOI: 10.4238/2014.January.8.9. View

11.

Lui V, Hedberg M, Li H, Vangara B, Pendleton K, Zeng Y . Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov. 2013; 3(7):761-9. PMC: 3710532. DOI: 10.1158/2159-8290.CD-13-0103. View

12.

Tu H, Chang K, Chiang W, Liu C, Yu E, Liu S . The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. Oral Oncol. 2011; 47(3):211-6. DOI: 10.1016/j.oraloncology.2011.01.003. View

13.

Okami K, Wu L, Riggins G, Cairns P, Goggins M, Evron E . Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res. 1998; 58(3):509-11. View

14.

Lam E, Chan J, Chan A, Ng C, Lo S, Lam V . Prevalence, Clinicopathological Characteristics, and Outcome of Human Papillomavirus-Associated Oropharyngeal Cancer in Southern Chinese Patients. Cancer Epidemiol Biomarkers Prev. 2015; 25(1):165-73. DOI: 10.1158/1055-9965.EPI-15-0869. View

15.

Sun W, Gaykalova D, Ochs M, Mambo E, Arnaoutakis D, Liu Y . Activation of the NOTCH pathway in head and neck cancer. Cancer Res. 2013; 74(4):1091-104. PMC: 3944644. DOI: 10.1158/0008-5472.CAN-13-1259. View

16.

Ndiaye C, Alemany L, Diop Y, Ndiaye N, Dieme M, Tous S . The role of human papillomavirus in head and neck cancer in Senegal. Infect Agent Cancer. 2013; 8(1):14. PMC: 3637397. DOI: 10.1186/1750-9378-8-14. View

17.

Chokunonga E, Borok M, Chirenje Z, Nyakabau A, Parkin D . Trends in the incidence of cancer in the black population of Harare, Zimbabwe 1991-2010. Int J Cancer. 2013; 133(3):721-9. DOI: 10.1002/ijc.28063. View

18.

Loeffler-Ragg J, Witsch-Baumgartner M, Tzankov A, Hilbe W, Schwentner I, Sprinzl G . Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma. Eur J Cancer. 2005; 42(1):109-11. DOI: 10.1016/j.ejca.2005.08.034. View

19.

Licitra L, Bossi P, Locati L . A multidisciplinary approach to squamous cell carcinomas of the head and neck: what is new?. Curr Opin Oncol. 2006; 18(3):253-7. DOI: 10.1097/01.cco.0000219254.53091.35. View

20.

Kuan E, Badran K, St John M . What is the role of human papillomavirus testing in head and neck cancer?. Laryngoscope. 2015; 125(12):2633-4. DOI: 10.1002/lary.25236. View