A Role for Bradykinin Signaling in Chronic Vulvar Pain

Overview

Journal J Pain

Specialties Neurology
Psychiatry

Date 2016 Aug 22

PMID 27544818

Citations 10

Authors

Megan L Falsetta

David C Foster

Collynn F Woeller

Stephen J Pollock

Adrienne D Bonham

Constantine G Haidaris

Richard P Phipps

Affiliations

Soon will be listed here.

Abstract

Perspective: There is an unmet need for the development of more effective vulvodynia therapies. As we explore the mechanisms by which human vulvar fibroblasts respond to proinflammatory/propain stimuli, we move closer to understanding the origins of chronic vulvar pain and identifying new therapeutic targets, knowledge that could significantly improve patient care.

Citing Articles

Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.

Nakhleh-Francis Y, Awad-Igbaria Y, Sakas R, Bang S, Abu-Ata S, Palzur E Int J Mol Sci. 2024; 25(8).

PMID: 38673846 PMC: 11050705. DOI: 10.3390/ijms25084261.

Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain.

Bekauri T, Fischer S, Honn K, Maddipati K, Love T, Little C Pain. 2023; 165(4):820-837.

PMID: 37889581 PMC: 10949218. DOI: 10.1097/j.pain.0000000000003088.

Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts.

Tonc E, Omwanda G, Tovar K, Golden X, Chatterjea D Front Cell Infect Microbiol. 2023; 13:1215380.

PMID: 37360527 PMC: 10285386. DOI: 10.3389/fcimb.2023.1215380.

Inflammation, lipids, and pain in vulvar disease.

Falsetta M, Maddipati K, Honn K Pharmacol Ther. 2023; 248:108467.

PMID: 37285943 PMC: 10527276. DOI: 10.1016/j.pharmthera.2023.108467.

A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases.

Rex D, Vaid N, Deepak K, Dagamajalu S, Keshava Prasad T Mol Biol Rep. 2022; 49(10):9915-9927.

PMID: 35596055 PMC: 9122735. DOI: 10.1007/s11033-022-07539-2.

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