Oritavancin in Vitro Activity Against Contemporary Staphylococcus Aureus Isolates Responsible for Invasive Community- and Healthcare-associated Infections Among Patients in the United States (2013-2014)

Oritavancin has been approved in the United States and European Union for the treatment of acute bacterial skin and skin structure infections caused by several Gram-positive pathogens including Staphylococcus aureus. In this study, the in vitro activity of oritavancin and comparator agents was assessed against 1008 isolates of contemporary invasive community- or healthcare-associated S. aureus (790 and 218 isolates, respectively). All sampled contemporary (2013-2014) S. aureus isolates were susceptible at ≤0.12μg/mL to oritavancin (MIC values, 0.03/0.06μg/mL), regardless of origin or susceptibility phenotype.