Untangling the Manganese-α-Synuclein Web

Overview

Journal Front Neurosci

Date 2016 Aug 20

PMID 27540354

Citations 17

Authors

Tanara Vieira Peres

Nancy L Parmalee

Ebany J Martinez-Finley

Michael Aschner

Affiliations

Soon will be listed here.

Abstract

Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and α-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process.

Citing Articles

Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism.

Ngwa H, Bargues-Carot A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A Int J Mol Sci. 2024; 25(10).

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Signaling Pathways Involved in Manganese-Induced Neurotoxicity.

Cheng H, Villahoz B, Ponzio R, Aschner M, Chen P Cells. 2023; 12(24).

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Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.

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Synucleinopathies: Intrinsic and Extrinsic Factors.

Lomeli-Lepe A, Castaneda-Cabral J, Lopez-Perez S Cell Biochem Biophys. 2023; 81(3):427-442.

PMID: 37526884 DOI: 10.1007/s12013-023-01154-z.

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.

Tinkov A, Paoliello M, Mazilina A, Skalny A, Martins A, Voskresenskaya O Int J Mol Sci. 2021; 22(9).

PMID: 33925013 PMC: 8124173. DOI: 10.3390/ijms22094646.

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