Short-term Reproducibility of Intraocular Pressure and Ocular Perfusion Pressure Measurements in Chinese Volunteers and Glaucoma Patients

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2016 Aug 20

PMID 27538515

Citations 6

Authors

Yanlin Gao

Bing Wan

Peiyu Li

Yan Zhang

Xin Tang

Affiliations

Soon will be listed here.

Abstract

Background: To evaluate the short-term reproducibility of diurnal intraocular pressure (IOP) and ocular perfusion pressure (OPP) measurements in normal volunteers, untreated normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients.

Methods: Fifty-four healthy volunteers (control group), 67 NTG patients and 54 POAG patients were recruited. The IOPs of both eyes were measured with a Goldmann applanation tonometer at 3-h intervals over 2 consecutive days. Blood pressure (BP) measurements were collected at the same times. The mean IOP/OPP, peak IOP/OPP, trough IOP/OPP and IOP/OPP fluctuations on each day were also calculated. The intraclass correlation coefficients (ICCs) were used to evaluate the reproducibilities.

Results: In the control group, the ICCs of mean IOP, peak IOP, trough IOP and IOP fluctuation were 0.921, 0.889, 0.888, and 0.661, respectively, and the ICCs of the mean OPP, peak OPP, trough OPP and OPP fluctuations were 0.962, 0.918, 0.953, and 0.680, respectively. In the NTG group, the ICCs of the mean IOP, peak IOP, trough IOP and IOP fluctuation were 0.862, 0.741, 0.798, and 0.290, respectively, and the ICCs of the mean OPP, peak OPP, trough OPP and OPP fluctuations were 0.947, 0.828, 0.927, and -0.008, respectively. In the POAG group, the ICCs of the mean IOP, peak IOP, trough IOP and IOP fluctuation were 0.857, 0.666, 0.808, and 0.546, respectively, and the ICCs of the mean OPP, peak OPP, trough OPP and OPP fluctuation were 0.934, 0.842, 0.910, and 0.093, respectively.

Conclusion: The IOP measurements within a single day were not highly reproducible in the short-term. The normal volunteers exhibited better IOP and OPP reproducibilities than the glaucoma patients. The IOP and OPP fluctuations could not be accurately evaluated based on the IOP or OPP measurements within a single day.

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References

Sehi M, Flanagan J, Zeng L, Cook R, Trope G . Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2005; 46(2):561-7. DOI: 10.1167/iovs.04-1033. View

Liu J, Zhang X, Kripke D, Weinreb R . Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci. 2003; 44(4):1586-90. DOI: 10.1167/iovs.02-0666. View

Choi J, Kim K, Jeong J, Cho H, Lee C, Kook M . Circadian fluctuation of mean ocular perfusion pressure is a consistent risk factor for normal-tension glaucoma. Invest Ophthalmol Vis Sci. 2007; 48(1):104-11. DOI: 10.1167/iovs.06-0615. View

Hatanaka M, Babic M, Susanna Jr R . Reproducibility of the mean, fluctuation, and IOP peak in the diurnal tension curve. J Glaucoma. 2012; 22(5):390-2. DOI: 10.1097/IJG.0b013e3182447a03. View

Konstas A, Irkec M, Teus M, Cvenkel B, Astakhov Y, Sharpe E . Mean intraocular pressure and progression based on corneal thickness in patients with ocular hypertension. Eye (Lond). 2007; 23(1):73-8. DOI: 10.1038/sj.eye.6702995. View

Song Y, Lee C, Kim J, Hong S, Kim C, Seong G . Instability of 24-hour intraocular pressure fluctuation in healthy young subjects: a prospective, cross-sectional study. BMC Ophthalmol. 2014; 14:127. PMC: 4232688. DOI: 10.1186/1471-2415-14-127. View

Hermida R, Ayala D, Portaluppi F . Circadian variation of blood pressure: the basis for the chronotherapy of hypertension. Adv Drug Deliv Rev. 2007; 59(9-10):904-22. DOI: 10.1016/j.addr.2006.08.003. View

Aptel F, Lesoin A, Chiquet C, Aryal-Charles N, Noel C, Romanet J . Long-term reproducibility of diurnal intraocular pressure patterns in patients with glaucoma. Ophthalmology. 2014; 121(10):1998-2003. DOI: 10.1016/j.ophtha.2014.04.039. View

Xu S, Jiao Q, Cheng Y, Sun J, Lu Q, Zhong Y . Short-Term Reproducibility of Twenty-Four-Hour Intraocular Pressure Curves in Untreated Patients with Primary Open-Angle Glaucoma and Ocular Hypertension. PLoS One. 2015; 10(10):e0140206. PMC: 4605594. DOI: 10.1371/journal.pone.0140206. View

10.

Sung K, Lee S, Park S, Choi J, Kim S, Yun S . Twenty-four hour ocular perfusion pressure fluctuation and risk of normal-tension glaucoma progression. Invest Ophthalmol Vis Sci. 2009; 50(11):5266-74. DOI: 10.1167/iovs.09-3716. View

11.

Fogagnolo P, Rossetti L, Mazzolani F, Orzalesi N . Circadian variations in central corneal thickness and intraocular pressure in patients with glaucoma. Br J Ophthalmol. 2005; 90(1):24-8. PMC: 1856876. DOI: 10.1136/bjo.2005.079285. View

12.

Rossetti L, Sacchi M, Karabatsas C, Topouzis F, Vetrugno M, Centofanti M . Comparison of the effects of bimatoprost and a fixed combination of latanoprost and timolol on 24-hour blood and ocular perfusion pressures: the results of a randomized trial. BMC Ophthalmol. 2015; 15:7. PMC: 4320581. DOI: 10.1186/1471-2415-15-7. View

13.

Mansouri K, Weinreb R, Liu J . Efficacy of a contact lens sensor for monitoring 24-h intraocular pressure related patterns. PLoS One. 2015; 10(5):e0125530. PMC: 4420265. DOI: 10.1371/journal.pone.0125530. View

14.

Realini T, Weinreb R, Wisniewski S . Diurnal intraocular pressure patterns are not repeatable in the short term in healthy individuals. Ophthalmology. 2010; 117(9):1700-4. PMC: 2934877. DOI: 10.1016/j.ophtha.2010.01.044. View

15.

Quaranta L, Konstas A, Rossetti L, Garcia-Feijoo J, OBrien C, Nasr M . Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry. Eye (Lond). 2009; 24(7):1252-8. DOI: 10.1038/eye.2009.300. View

16.

Bonomi L, Marchini G, Marraffa M, Bernardi P, Morbio R, Varotto A . Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study. Ophthalmology. 2000; 107(7):1287-93. DOI: 10.1016/s0161-6420(00)00138-x. View

17.

Quaranta L, Katsanos A, Russo A, Riva I . 24-hour intraocular pressure and ocular perfusion pressure in glaucoma. Surv Ophthalmol. 2012; 58(1):26-41. DOI: 10.1016/j.survophthal.2012.05.003. View

18.

. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators. Am J Ophthalmol. 2000; 130(4):429-40. DOI: 10.1016/s0002-9394(00)00538-9. View

19.

Fogagnolo P, Capizzi F, Orzalesi N, Figus M, Ferreras A, Rossetti L . Can mean central corneal thickness and its 24-hour fluctuation influence fluctuation of intraocular pressure?. J Glaucoma. 2009; 19(6):418-23. DOI: 10.1097/IJG.0b013e3181aff432. View

20.

Realini T, Weinreb R, Weinreb N, Wisniewski S . Short-term repeatability of diurnal intraocular pressure patterns in glaucomatous individuals. Ophthalmology. 2010; 118(1):47-51. DOI: 10.1016/j.ophtha.2010.04.027. View