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Medical Treatment of Ankylosing Spondylitis

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Journal Hip Pelvis
Date 2016 Aug 19
PMID 27536570
Citations 11
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Abstract

The diagnosis of ankylosing spondylitis is often delayed due to ambiguous clinical manifestations and strict diagnostic criteria. However, imaging techniques such as magnetic resonance imaging have been found effective for the early diagnosis of non-radiographic sacroiliitis. New tumor necrosis factor alpha (TNF-α) inhibitors have good efficacy for patients with persistently high disease activity despite conventional nonsteroidal anti-inflammatory drug treatment. Thus, early diagnosis and aggressive treatments are essential for ankylosing spondylitis patients. Because many patients complain of musculoskeletal pains, especially around the sacroiliac joint area, hip specialists should be informed of up-to-date knowledge. In this review, we discuss new diagnostic criteria for ankylosing spondylitis, administration methods of TNF-α inhibitors, and the long-term follow-up results for patients treated with TNF-α inhibitors.

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References
1.
Bruner V, Atteno M, Spano A, Scarpa R, Peluso R . Biological therapies for spondyloarthritis. Ther Adv Musculoskelet Dis. 2014; 6(3):92-101. PMC: 4040940. DOI: 10.1177/1759720X14535512. View

2.
Maxwell L, Zochling J, Boonen A, Singh J, Veras M, Tanjong Ghogomu E . TNF-alpha inhibitors for ankylosing spondylitis. Cochrane Database Syst Rev. 2015; (4):CD005468. PMC: 11200207. DOI: 10.1002/14651858.CD005468.pub2. View

3.
Braun J, van den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez E . 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis. 2011; 70(6):896-904. PMC: 3086052. DOI: 10.1136/ard.2011.151027. View

4.
Barkham N, Keen H, Coates L, OConnor P, Hensor E, Fraser A . Clinical and imaging efficacy of infliximab in HLA-B27-Positive patients with magnetic resonance imaging-determined early sacroiliitis. Arthritis Rheum. 2009; 60(4):946-54. DOI: 10.1002/art.24408. View

5.
Rudwaleit M, Metter A, Listing J, Sieper J, Braun J . Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum. 2006; 54(2):569-78. DOI: 10.1002/art.21619. View