Sol Narae (Sona) is a Drosophila ADAMTS Involved in Wg Signaling

Overview

Journal Sci Rep

Specialty Science

Date 2016 Aug 19

PMID 27535473

Citations 11

Authors

Go-Woon Kim

Jong-Hoon Won

Ok-Kyung Lee

Sang-Soo Lee

Jeong-Hoon Han

Orkhon Tsogtbaatar

Sujin Nam

Yeon Kim

Kyung-Ok Cho

Affiliations

Soon will be listed here.

Abstract

ADAMTS (a disintegrin and metalloproteases with thrombospondin motif) family consists of secreted proteases, and is shown to cleave extracellular matrix proteins. Their malfunctions result in cancers and disorders in connective tissues. We report here that a Drosophila ADAMTS named Sol narae (Sona) promotes Wnt/Wingless (Wg) signaling. sona loss-of-function mutants are lethal and rare escapers had malformed appendages, indicating that sona is essential for fly development and survival. sona exhibited positive genetic interaction with wntless (wls) that encodes a cargo protein for Wg. Loss of sona decreased the level of extracellular Wg, and also reduced the expression level of Wg effector proteins such as Senseless (Sens), Distalless (Dll) and Vestigial (Vg). Sona and Wg colocalized in Golgi and endosomal vesicles, and were in the same protein complex. Furthermore, co-expression of Wg and Sona generated ectopic wing margin bristles. This study suggests that Sona is involved in Wg signaling by regulating the level of extracellular Wg.

Citing Articles

Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegypti.

Herd C, Yu X, Cui Y, Franz A Insect Biochem Mol Biol. 2022; 148:103815.

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Dynein Heavy Chain 64C Differentially Regulates Cell Survival and Proliferation of Wingless-Producing Cells in .

Kim J, Tsogtbaatar O, Cho K J Dev Biol. 2021; 9(4).

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Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in .

Cho D, Lee S, Cho K Mol Cells. 2021; 44(1):13-25.

PMID: 33510049 PMC: 7854181. DOI: 10.14348/molcells.2020.0244.

Exosomal arrow (Arr)/lipoprotein receptor protein 6 (LRP6) in Drosophila melanogaster increases the extracellular level of Sol narae (Sona) in a Wnt-independent manner.

Han J, Kim Y, Cho K Cell Death Dis. 2020; 11(11):944.

PMID: 33139721 PMC: 7608652. DOI: 10.1038/s41419-020-02850-x.

Wg secreted by conventional Golgi transport diffuses and forms Wg gradient whereas Wg tethered to extracellular vesicles do not diffuse.

Won J, Cho K Cell Death Differ. 2020; 28(3):1013-1025.

PMID: 33028960 PMC: 7937861. DOI: 10.1038/s41418-020-00632-8.

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