Angiopoietin-like Protein 1 Antagonizes MET Receptor Activity to Repress Sorafenib Resistance and Cancer Stemness in Hepatocellular Carcinoma

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2016 Aug 18

PMID 27530187

Citations 61

Authors

Hsin-An Chen

Tsang-Chih Kuo

Chi-Feng Tseng

Jui-Ti Ma

Shu-Ting Yang

Chia-Jui Yen

Ching-Yao Yang

Shian-Ying Sung

Jen-Liang Su

Affiliations

Soon will be listed here.

Abstract

Conclusion: ANGPTL1 inhibits sorafenib resistance and cancer stemness in HCC cells by repressing EMT through inhibition of the MET receptor-AKT/ERK-Egr-1-Slug signaling cascade. ANGPTL1 may serve as a novel MET receptor inhibitor for advanced HCC therapy. (Hepatology 2016;64:1637-1651).

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