High-Intensity Locomotor Exercise Increases Brain-Derived Neurotrophic Factor in Individuals with Incomplete Spinal Cord Injury

Overview

Journal J Neurotrauma

Publisher Mary Ann Liebert

Specialties Emergency Medicine
Neurology

Date 2016 Aug 17

PMID 27526567

Citations 46

Authors

Kristan A Leech

T George Hornby

Affiliations

Soon will be listed here.

Abstract

High-intensity locomotor exercise is suggested to contribute to improved recovery of locomotor function after neurological injury. This may be secondary to exercise-intensity-dependent increases in neurotrophin expression demonstrated previously in control subjects. However, rigorous examination of intensity-dependent changes in neurotrophin levels is lacking in individuals with motor incomplete spinal cord injury (SCI). Therefore, the primary aim of this study was to evaluate the effect of locomotor exercise intensity on peripheral levels of brain-derived neurotrophic factor (BDNF) in individuals with incomplete SCI. We also explored the impact of the Val66Met single-nucleotide polymorphism (SNP) on the BDNF gene on intensity-dependent changes. Serum concentrations of BDNF and insulin-like growth factor-1 (IGF-1), as well as measures of cardiorespiratory dynamics, were evaluated across different levels of exercise intensity achieved during a graded-intensity, locomotor exercise paradigm in 11 individuals with incomplete SCI. Our results demonstrate a significant increase in serum BDNF at high, as compared to moderate, exercise intensities (p = 0.01) and 15 and 30 min post-exercise (p < 0.01 for both), with comparison to changes at low intensity approaching significance (p = 0.05). Serum IGF-1 demonstrated no intensity-dependent changes. Significant correlations were observed between changes in BDNF and specific indicators of exercise intensity (e.g., rating of perceived exertion; R = 0.43; p = 0.02). Additionally, the data suggest that Val66Met SNP carriers may not exhibit intensity-dependent changes in serum BDNF concentration. Given the known role of BDNF in experience-dependent neuroplasticity, these preliminary results suggest that exercise intensity modulates serum BDNF concentrations and may be an important parameter of physical rehabilitation interventions after neurological injury.

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References

Statton M, Encarnacion M, Celnik P, Bastian A . A Single Bout of Moderate Aerobic Exercise Improves Motor Skill Acquisition. PLoS One. 2015; 10(10):e0141393. PMC: 4624775. DOI: 10.1371/journal.pone.0141393. View

Witte A, Kurten J, Jansen S, Schirmacher A, Brand E, Sommer J . Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity. J Neurosci. 2012; 32(13):4553-61. PMC: 6622078. DOI: 10.1523/JNEUROSCI.6010-11.2012. View

Boyce V, Mendell L . Neurotrophins and spinal circuit function. Front Neural Circuits. 2014; 8:59. PMC: 4046666. DOI: 10.3389/fncir.2014.00059. View

Yoshii A, Constantine-Paton M . Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol. 2010; 70(5):304-22. PMC: 2923204. DOI: 10.1002/dneu.20765. View

Martinowich K, Lu B . Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology. 2007; 33(1):73-83. DOI: 10.1038/sj.npp.1301571. View

Chaieb L, Antal A, Ambrus G, Paulus W . Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols. Neurogenetics. 2014; 15(1):1-11. DOI: 10.1007/s10048-014-0393-1. View

Jung S, Kim J, Davis J, Blair S, Cho H . Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men. Eur J Appl Physiol. 2010; 111(2):303-11. DOI: 10.1007/s00421-010-1658-5. View

Cheeran B, Talelli P, Mori F, Koch G, Suppa A, Edwards M . A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. J Physiol. 2008; 586(23):5717-25. PMC: 2655403. DOI: 10.1113/jphysiol.2008.159905. View

Boyce V, Mendell L . Neurotrophic factors in spinal cord injury. Handb Exp Pharmacol. 2014; 220:443-60. DOI: 10.1007/978-3-642-45106-5_16. View

10.

Cotman C, Berchtold N . Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002; 25(6):295-301. DOI: 10.1016/s0166-2236(02)02143-4. View

11.

Ding Q, Vaynman S, Akhavan M, Ying Z, Gomez-Pinilla F . Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Neuroscience. 2006; 140(3):823-33. DOI: 10.1016/j.neuroscience.2006.02.084. View

12.

Egan M, Kojima M, Callicott J, Goldberg T, Kolachana B, Bertolino A . The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003; 112(2):257-69. DOI: 10.1016/s0092-8674(03)00035-7. View

13.

Leech K, Kinnaird C, Hornby T . Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury. J Neurotrauma. 2014; 31(15):1334-42. PMC: 4121052. DOI: 10.1089/neu.2013.3206. View

14.

Moore J, Roth E, Killian C, Hornby T . Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery. Stroke. 2009; 41(1):129-35. DOI: 10.1161/STROKEAHA.109.563247. View

15.

Rojas Vega S, Struder H, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W . Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res. 2006; 1121(1):59-65. DOI: 10.1016/j.brainres.2006.08.105. View

16.

Kerschensteiner M, Gallmeier E, Behrens L, Leal V, Misgeld T, Klinkert W . Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J Exp Med. 1999; 189(5):865-70. PMC: 2192942. DOI: 10.1084/jem.189.5.865. View

17.

Gomez-Pinilla F, Ying Z, Roy R, Molteni R, Edgerton V . Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol. 2002; 88(5):2187-95. DOI: 10.1152/jn.00152.2002. View

18.

Goekint M, Heyman E, Roelands B, Njemini R, Bautmans I, Mets T . No influence of noradrenaline manipulation on acute exercise-induced increase of brain-derived neurotrophic factor. Med Sci Sports Exerc. 2008; 40(11):1990-6. DOI: 10.1249/MSS.0b013e31817eee85. View

19.

NGuyen U, Mougin F, Simon-Rigaud M, Rouillon J, Marguet P, Regnard J . Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. Eur J Appl Physiol Occup Physiol. 1998; 78(6):533-7. DOI: 10.1007/s004210050456. View

20.

Gorman P, Scott W, York H, Theyagaraj M, Price-Miller N, McQuaid J . Robotically assisted treadmill exercise training for improving peak fitness in chronic motor incomplete spinal cord injury: A randomized controlled trial. J Spinal Cord Med. 2014; 39(1):32-44. PMC: 4725790. DOI: 10.1179/2045772314Y.0000000281. View