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Antenatal Treatment of Fetal Alloimmune Cytopenias

Overview
Journal Blut
Specialty Hematology
Date 1989 Jul 1
PMID 2752171
Citations 1
Authors
J B Bussel
J G McFarland
R Berkowitz
Affiliations
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Abstract

The antenatal use of intravenous immunoglobulin (IVG) was explored in 9 cases of alloimmune cytopenias affecting fetuses. In 7 cases of alloimmune thrombocytopenia, IVG at a dose of 1 gm/kg/week appeared to be uniformly effective in elevating the fetal platelet count and preventing a recurrence of antenatal intracranial hemorrhage (2 cases). In 2 cases of Rh disease the results were more equivocal. There did not appear to be any significant toxicity associated with its use. The mechanism of IVG effect in the successfully treated cases remains uncertain.

Citing Articles

IVIG therapy in neonatal isoimmune thrombocytopenic purpura and alloimmunization thrombocytopenia.

Kurtzberg J, Dunsmore K Clin Rev Allergy. 1992; 10(1-2):73-80.

PMID: 1606525 DOI: 10.1007/978-1-4612-0417-6_6.

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