Sonic Hedgehog Protein : A Novel Approach to the Treatment of Neurodegenerative Disorders?

Overview

Journal CNS Drugs

Specialties Neurology
Pharmacology

Date 2016 Aug 14

PMID 27521008

Authors

K Pang

T D Ingolia

Affiliations

Soon will be listed here.

Abstract

Sonic hedgehog is a member of a newly discovered family of molecules that are active during development in vertebrates. Sonic hedgehog induces development of key CNS neuronal cell types, including the dopaminergic neurons that are destroyed in Parkinson's disease. In addition to developmental-inducing activity, Sonic hedgehog has neurotrophic and neuroprotective activities on many of these same cell types. These activities suggest interesting clinical potentials for Sonic hedgehog in neurodegenerative diseases such as Parkinson's disease and in acute CNS trauma such as stroke.

References

Quinn N . Drug treatment of Parkinson's disease. BMJ. 1995; 310(6979):575-9. PMC: 2548944. DOI: 10.1136/bmj.310.6979.575. View

Eriksson N, Lindsay R, Aldskogius H . BDNF and NT-3 rescue sensory but not motoneurones following axotomy in the neonate. Neuroreport. 1994; 5(12):1445-8. View

Casper D, Mytilineou C, Blum M . EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture. J Neurosci Res. 1991; 30(2):372-81. DOI: 10.1002/jnr.490300213. View

Tanabe Y, Roelink H, Jessell T . Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Curr Biol. 1995; 5(6):651-8. DOI: 10.1016/s0960-9822(95)00130-8. View

Gao W, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M . Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann Neurol. 1995; 38(1):30-7. DOI: 10.1002/ana.410380108. View

Ernfors P, Lee K, Jaenisch R . Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994; 368(6467):147-50. DOI: 10.1038/368147a0. View

Hynes M, Poulsen K, Armanini M, Berkemeier L, Phillips H, Rosenthal A . Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J Neurosci Res. 1994; 37(1):144-54. DOI: 10.1002/jnr.490370118. View

Nikkhah G, Odin P, Smits A, Tingstrom A, Othberg A, Brundin P . Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture. Exp Brain Res. 1993; 92(3):516-23. DOI: 10.1007/BF00229041. View

Miao N, Wang M, Ott J, DAlessandro J, Woolf T, Bumcrot D . Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro. J Neurosci. 1997; 17(15):5891-9. PMC: 6573190. View

10.

Poulsen K, Armanini M, Klein R, Hynes M, PHILLIPS H, Rosenthal A . TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron. 1994; 13(5):1245-52. DOI: 10.1016/0896-6273(94)90062-0. View

11.

Krieglstein K, Suter-Crazzolara C, Fischer W, Unsicker K . TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. 1995; 14(4):736-42. PMC: 398139. DOI: 10.1002/j.1460-2075.1995.tb07052.x. View

12.

Hynes M, Porter J, Chiang C, Chang D, Tessier-Lavigne M, Beachy P . Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron. 1995; 15(1):35-44. DOI: 10.1016/0896-6273(95)90062-4. View

13.

Wang M, Jin P, Bumcrot D, Marigo V, McMahon A, Wang E . Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat Med. 1995; 1(11):1184-8. DOI: 10.1038/nm1195-1184. View

14.

Bitgood M, Shen L, McMahon A . Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996; 6(3):298-304. DOI: 10.1016/s0960-9822(02)00480-3. View

15.

Tabata T, Eaton S, Kornberg T . The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 1992; 6(12B):2635-45. DOI: 10.1101/gad.6.12b.2635. View

16.

Porter J, Young K, Beachy P . Cholesterol modification of hedgehog signaling proteins in animal development. Science. 1996; 274(5285):255-9. DOI: 10.1126/science.274.5285.255. View

17.

Echelard Y, Epstein D, St-Jacques B, Shen L, Mohler J, McMahon J . Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993; 75(7):1417-30. DOI: 10.1016/0092-8674(93)90627-3. View

18.

Giacobini M, ALMSTROM S, Funa K, Olson L . Differential effects of platelet-derived growth factor isoforms on dopamine neurons in vivo: -BB supports cell survival, -AA enhances fiber formation. Neuroscience. 1993; 57(4):923-9. DOI: 10.1016/0306-4522(93)90038-h. View

19.

McMahon S, Priestley J . Peripheral neuropathies and neurotrophic factors: animal models and clinical perspectives. Curr Opin Neurobiol. 1995; 5(5):616-24. DOI: 10.1016/0959-4388(95)80067-0. View

20.

Mocchetti I, Wrathall J . Neurotrophic factors in central nervous system trauma. J Neurotrauma. 1995; 12(5):853-70. DOI: 10.1089/neu.1995.12.853. View