» Articles » PMID: 27519661

ENPP1 and ESR1 Genotypes Influence Temporomandibular Disorders Development and Surgical Treatment Response in Dentofacial Deformities

Overview
Publisher Elsevier
Date 2016 Aug 14
PMID 27519661
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Unlabelled: Dentofacial deformities are dys-morpho-functional disorders involving the temporomandibular joints (TMJ). Many authors have reported a TMJ improvement in dysfunctional subjects with malocclusion after orthodontic or combined orthodontic and surgical treatment particularly for the relief of pain. In particular, few studies have highlighted the demographic and clinical predictors of response to surgical treatment. To date, no genetic factor has yet been identified as a predictor of response to surgical treatment. The aim of this cohort study is therefore to identify single-nucleotide polymorphisms associated with postoperative temporomandibular disorders (TMD) or with TMJ symptoms after orthognathic surgery. Here, we found the AA genotype of SNP rs1643821 (ESR1 gene) as a risk factor for dysfunctional worsening after orthognathic surgery. In addition, we have identified TT genotype of SNP rs858339 (ENPP1 gene) as a protective factor against TMD in a population of patients with dentofacial deformities. Conversely, the heterozygous genotype AT was identified as a risk factor of TMD with respect to the rest of our population. All these elements are particularly important to bring new screening strategies and tailor future treatment.

Perspective: This study allows us to identify sub-populations at high risk of developing postoperative temporomandibular disorders after orthognathic surgery procedures. Many other genes of interest could be potential factors influencing the dysfunctional response to orthognathic surgery, particularly genes of the Opera cohort.

Citing Articles

Association of Catechol-O-Methyl-Transferase and Estrogen Receptors polymorphism with Severity of Temporomandibular Disorder in Iranian Patients.

Roudgari H, Najafi S, Khalilian S, Ghafarzadeh Z, Hahakzadeh A, Behazin S Avicenna J Med Biotechnol. 2023; 15(4):245-252.

PMID: 38078344 PMC: 10709752. DOI: 10.18502/ajmb.v15i4.13498.


Genetic polymorphisms are involved in oral health-related quality of life in skeletal class III patients submitted to orthognathic surgery.

Meger M, Gerber J, Azeredo W, Sebastiani A, Deliberador T, Kuchler E Clin Oral Investig. 2023; 27(4):1409-1421.

PMID: 36826515 DOI: 10.1007/s00784-023-04925-3.


Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.

Cruz D, Monteiro F, Paco M, Vaz-Silva M, Lemos C, Alves-Ferreira M Jpn Dent Sci Rev. 2022; 58:69-88.

PMID: 35242249 PMC: 8881721. DOI: 10.1016/j.jdsr.2022.02.002.


Condyle modeling stability, craniofacial asymmetry and ACTN3 genotypes: Contribution to TMD prevalence in a cohort of dentofacial deformities.

Nicot R, Chung K, Vieira A, Raoul G, Ferri J, Sciote J PLoS One. 2020; 15(7):e0236425.

PMID: 32726330 PMC: 7390436. DOI: 10.1371/journal.pone.0236425.


TMJ related short-term outcomes comparing two different osteosynthesis techniques for bilateral sagittal split osteotomy.

Roland-Billecart T, Raoul G, Kyheng M, Sciote J, Ferri J, Nicot R J Stomatol Oral Maxillofac Surg. 2020; 122(1):70-76.

PMID: 32229181 PMC: 8787860. DOI: 10.1016/j.jormas.2020.03.018.


References
1.
Scolozzi P, Wandeler P, Courvoisier D . Can clinical factors predict postoperative temporomandibular disorders in orthognathic patients? A retrospective study of 219 patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 119(5):531-8. DOI: 10.1016/j.oooo.2015.01.006. View

2.
Dicker G, Castelijns J, Tuinzing D, Stoelinga P . Do the changes in muscle mass, muscle direction, and rotations of the condyles that occur after sagittal split advancement osteotomies play a role in the aetiology of progressive condylar resorption?. Int J Oral Maxillofac Surg. 2015; 44(5):627-31. DOI: 10.1016/j.ijom.2015.01.001. View

3.
Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S . Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet. 1998; 19(3):271-3. DOI: 10.1038/956. View

4.
Pacifici R . Cytokines, estrogen, and postmenopausal osteoporosis--the second decade. Endocrinology. 1998; 139(6):2659-61. DOI: 10.1210/endo.139.6.6087. View

5.
McEwen B, Alves S . Estrogen actions in the central nervous system. Endocr Rev. 1999; 20(3):279-307. DOI: 10.1210/edrv.20.3.0365. View