A New Bronchodilator, Rimiterol Hydrobromide (R 798): An Open Study of the Bronchodilator, Cardiovascular and Arterial Oxygen Changes in Asthmatic Patients

Overview

Journal Ir J Med Sci

Specialty General Medicine

Date 2016 Aug 13

PMID 27518949

Citations 1

Authors

W D Linehan

Affiliations

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Abstract

IN this study, rimiterol has been shown to have a rapid, potent and fairly well maintained bronchodilator effect when given as an aerosol.When given in doses of three (1.5 mg.) and nine (4.5 mg.) times a previously reported 'reference' dose (0.5 mg.), there were no statistically significant increases in heart rate and no untoward changes in the electrocardiogram.The small reductions in arterial oxygen saturation recorded were appreciably less than those reported for the same patients after exercise.The circadian variation in P.E.F.R. was measured in four asthmatic patients and the increase occurring in the afternoon may mask the waning effect of a bronchodilator drug. This would appear to increase the difficulty of interpreting the results of bronchodilator trials extending over several hours.

Citing Articles

Rimiterol: a review of its pharmacological properties and therapeutic efficacy in asthma.

Pinder R, Brogden R, Speight T, Avery G Drugs. 1977; 14(2):81-104.

PMID: 19226 DOI: 10.2165/00003495-197714020-00001.

References

INGRAM Jr R, Krumpe P, Duffell G, Maniscalco B . Ventilation-perfusion changes after aerosolized isoproterenol in asthma. Am Rev Respir Dis. 1970; 101(3):364-70. DOI: 10.1164/arrd.1970.101.3.364. View

Cooke N, Kerr J, Willey R, Hoare M, GRANT I, Cromptom G . Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1974; 2(5913):250-2. PMC: 1610528. DOI: 10.1136/bmj.2.5913.250. View

Phillips E, Woolnough M, Marinova V, Turner P . A comparison of isoprenaline, salbutamol, and rimiterol inhalation on skin temperature, heart rate, and respiration in man. J Clin Pharmacol New Drugs. 1972; 12(4):158-68. DOI: 10.1002/j.1552-4604.1972.tb00045.x. View

Field G . The effects of posture, oxygen, isoproterenol and atropine on ventilation-perfusion relationships in the lung in asthma. Clin Sci. 1967; 32(2):279-88. View

Warrell D, Robertson D, Howes J, Conolly M, Paterson J, Beilin L . Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma. Br Med J. 1970; 1(5688):65-70. PMC: 1699164. View

Harris L . Comparison of the effect on blood gases, ventilation, and perfusion of isoproterenol-phenylephrine and salbutamol aerosols in chronic bronchitis with asthma. J Allergy Clin Immunol. 1972; 49(2):63-71. DOI: 10.1016/0091-6749(72)90057-7. View

Bowman W, Rodger I . Actions of the sympathomimetic bronchodilator, rimiterol (R798), on the cardiovascular, respiratory and skeletal muscle systems of the anaesthetized cat. Br J Pharmacol. 1972; 45(4):574-83. PMC: 1665966. DOI: 10.1111/j.1476-5381.1972.tb08115.x. View

Carney I, Daly M, LIGHTOWLER J, PICKERING R . The comparative pharmacology of WG253 (rimiterol hydrobromide), a new bronchodilator. Arch Int Pharmacodyn Ther. 1971; 194(2):334-45. View

Turner P, Griffin J . Antagonism of acetylcholine-induced bronchospasm by WG 253, a new sympathomimetic amine. J Pharm Pharmacol. 1971; 23(8):632. DOI: 10.1111/j.2042-7158.1971.tb08732.x. View

10.

HARRIS L . Effects of isoprenaline plus phenylephrine by pressurized aerosol on blood gases, ventilation, and perfusion in chronic obstructive lung disease. Br Med J. 1970; 4(5735):579-82. PMC: 1820193. DOI: 10.1136/bmj.4.5735.579. View

11.

Prime F, Kamburoff P . Single shots v. divided doses of a bronchodilator in the relief of reversible airways obstruction. Lancet. 1972; 1(7753):753. DOI: 10.1016/s0140-6736(72)90274-7. View

12.

Reinberg A, Gervais P, Frambourg J, Halberg F, Abulker C, Vignaud D . [Circadian rhythm of respiratory functions and temperature in asthmatic patients staying in hypoallergenic environment]. Presse Med (1893). 1970; 78(42):1817-21. View

13.

SVEDMYR N, MALMBERG R, Thiringer G . The effect of a new adrenergic beta 2 -receptor-stimulating agent (rimiterol, R798) in patients with chronic obstructive lung disease. Scand J Respir Dis. 1972; 53(5):302-13. View

14.

Griffin J, Turner P . Preliminary studies of a new bronchodilator (WG 253) in man. J Clin Pharmacol New Drugs. 1971; 11(4):280-7. View

15.

KNUDSON R, CONSTANTINE H . An effect of isoproterenol on ventilation-perfusion in asthmatic versus normal subjects. J Appl Physiol. 1967; 22(3):402-6. DOI: 10.1152/jappl.1967.22.3.402. View

16.

Tai E, Read J . Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967; 22(6):543-9. PMC: 471711. DOI: 10.1136/thx.22.6.543. View

17.

Chapman T, Hughes D . Increasing hypoxia in chronic lung disease following administration of a bronchodilator. J Ir Med Assoc. 1966; 59(354):184-9. View